1. Universidade Federal do Rio Grande do Norte
  2. Instituto do Cérebro
  3. ICe - Artigos publicados em periódicos
Use este identificador para citar ou linkar para este item: https://repositorio.ufrn.br/handle/123456789/27913
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dc.contributor.authorMoura, Daniela M. S.-
dc.contributor.authorSales, Igor R. P.-
dc.contributor.authorBrandão, Juliana A.-
dc.contributor.authorCosta, Marcos Romualdo-
dc.contributor.authorQueiroz, Claudio Marcos Teixeira de-
dc.date.accessioned2019-11-13T17:33:45Z-
dc.date.available2019-11-13T17:33:45Z-
dc.date.issued2019-11-05-
dc.identifier.citationMOURA, D. M. S.; SALES, I. R. P.; BRANDÃO, J. A.; COSTA, M. R.; QUEIROZ, C. M. Disentangling chemical and electrical effects of statusepilepticus-induced dentate gyrus abnormalities. Epilepsy & Behavior, nov. 2019. Doi: 10.1016/j.yebeh.2019.106575pt_BR
dc.identifier.urihttps://repositorio.ufrn.br/jspui/handle/123456789/27913-
dc.languageenpt_BR
dc.subjectEpilepsypt_BR
dc.subjectintrahippocampalpt_BR
dc.subjectadult neurogenesispt_BR
dc.subjectgranular cell dispersionpt_BR
dc.subjectectopic neuronspt_BR
dc.subjecthilar basal dendritespt_BR
dc.titleDisentangling chemical and electrical effects of status epilepticus-induced dentate gyrus abnormalitiespt_BR
dc.typearticlept_BR
dc.identifier.doihttps://doi.org/10.1016/j.yebeh.2019.106575-
dc.description.resumoIn rodents, status epilepticus (SE) triggered by chemoconvulsants can differently affect the proliferation and fate of adult-born dentate granule cells (DGCs). It is unknown whether abnormal neurogenesis results from intracellular signaling associated with drug-receptor interaction, paroxysmal activity, or both. To test the contribution of these factors, we systematically compared the effects of kainic acid (KA)- and pilocarpine (PL)-induced SE on the morphology and localization of DGCs generated before or after SE in the ipsi- and contralateral hippocampi of mice. Hippocampal insult was induced by unilateral intrahippocampal (ihpc) administration of KA or PL. We employed conditional doublecortin-dependent expression of the green fluorescent protein (GFP) to label adult-born cells committed to neuronal lineage either one month before (mature DGCs) or seven days after (immature DGCs) SE. Unilateral ihpc administration of KA and PL led to bilateral epileptiform discharges and focal and generalized behavioral seizures. However, drastic granule cell layer (GCL) dispersion occurred only in the ipsilateral side of KA injection, but not in PL-treated animals. Granule cell layer dispersion was accompanied by a significant reduction in neurogenesis after SE in the ipsilateral side of KA-treated animals, while neurogenesis increased in the contralateral side of KA-treated animals and both hippocampi of PL-treated animals. The ratio of ectopic neurons in the ipsilateral hippocampus was higher among immature as compared to mature neurons in the KA model (32.8% vs. 10.0%, respectively), while the occurrence of ectopic neurons in PL-treated animals was lower than 3% among both mature and immature DGCs. Collectively, our results suggest that KA- and PL-induced SE leads to distinct cellular alterations in mature and immature DGCs. We also show different local and secondary effects of KA or PL in the histological organization of the adult DG, suggesting that these unique epilepsy models may be complementary to our understanding of the disease.pt_BR
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