1. Universidade Federal do Rio Grande do Norte
2. Escola Multicampi de Ciências Médicas do Rio Grande do Norte
3. EMCM - Artigos publicados em periódicos

Título:	PAI-1 expression in intratumoral inflammatory infiltrate contributes to lymph node metastasis in oral cancer: a cross-sectional study
Autor(es):	Oliveira, Mayara Mota de Peterle, Gabriela Tonini Couto, Cinthia Vidal Monteiro da Silva Maia, Lucas de Lima Kühl, Andre Santos, Joaquim Gasparini dos Moysés, Raquel Ajub Trivilin, Leonardo Oliveira Borçoi, Aline Ribeiro Archanjo, Anderson Barros Assis, Arícia Leone Evangelista Monteiro de Nunes, Fábio Daumas Santos, Marcelo dos Silva, Adriana Madeira Álvares da
Palavras-chave:	PAI-1;Oral squamous cell carcinoma;Lymph node;Prognostic marker
Data do documento:	15-Abr-2021
Editor:	Elsevier
Referência:	OLIVEIRA, Mayara Mota de et al. PAI-1 expression in intratumoral inflammatory infiltrate contributes to lymph node metastasis in oral cancer: a cross-sectional study. Annals of Medicine and Surgery, [s. l.], v. 65, p. 1-6, 15 abr. 2021. Disponível em: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8167432/. Acesso em: 28 jan. 2022. http://doi.org/10.1016/j.amsu.2021.102303
Resumo:	Introduction: Immune cells contribute with mediators in the protein expression profile of the tumor microenvi ronment. Levels of plasminogen activator inhibitor-1 (PAI-1) are elevated in non-malignant inflammatory con ditions; however, the association between PAI-1 expression and inflammation remains uncertain in oral squamous cell carcinoma (OSCC). This study aimed to investigate PAI-1 expression in mononuclear inflammatory cell infiltrate in OSCC and its role as a prognostic marker. Methods: Samples were collected from patients with OSCC, treated surgically, and followed for 24 months after the procedure. Thirty-nine tumoral tissue were analyzed using immunohistochemistry. Correlation between protein expression, clinicopathological parameters, and the prognosis was investigated. Results: Positive PAI-1 expression in mononuclear inflammatory cell infiltrate was significantly associated with lymph node status (p = 0.009) and with the cytoplasmic expression of vascular endothelial growth factor A (VEGFA) (p = 0.028). Multivariate analysis revealed weak PAI-1 expression as an independent marker for lymph node metastases, with approximately 8-fold increased risk compared to strong expression (OR = 8.60; CI =1.54–48.08; p = 0.014). Conclusion: Our results suggest that the strong PAI-1 expression in intratumoral inflammatory infiltrate is an indicator of a better prognosis for patients diagnosed with oral squamous cell carcinoma.
URI:	https://repositorio.ufrn.br/handle/123456789/45745
ISSN:	2049-0801 (online)
Aparece nas coleções:	EMCM - Artigos publicados em periódicos

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