1. Universidade Federal do Rio Grande do Norte
2. Instituto do Cérebro
3. ICe - Artigos publicados em periódicos

Título:	Moderators of ayahuasca’s biological antidepressant action
Autor(es):	Sousa Júnior, Geovan Menezes de Tavares, Vagner Deuel de Oliveira Galvão, Ana Cecília de Menezes Almeida, Raíssa Nóbrega de Fontes, Fernanda Palhano Xavier de Soares, Bruno Lobão Freire, Fúlvio Aurélio de Morais Nunes, Emerson Arcoverde Oliveira, João Paulo Maia de Perkins, Daniel Sarris, Jerome Araujo, Draulio Barros de Coelho, Nicole Leite Galvão
Palavras-chave:	Brain-derived neurotrophic factor;Hydrocortisone;Cortisol;Depression;Hallucinogens;Psychedelics;Banisteriopsis;Ayahuasca
Data do documento:	Dez-2022
Editor:	Frontiers Media SA
Referência:	SOUSA, Geovan Menezes de; TAVARES, Vagner Deuel de Oliveira; GALVÃO, Ana Cecília de Menezes; ALMEIDA, Raíssa Nóbrega de; PALHANO-FONTES, Fernanda; LOBÃO-SOARES, Bruno; FREIRE, Fúlvio Aurélio de Morais; NUNES, Emerson Arcoverde; MAIA-DE-OLIVEIRA, João Paulo; PERKINS, Daniel; SARRIS, Jerome; ARAUJO, Draulio Barros de; GALVÃO-COELHO, Nicole Leite. Moderators of ayahuasca’s biological antidepressant action. Frontiers In Psychiatry, [S. l.], v. 13, p. 1033816, dez. 2022. Doi: http://dx.doi.org/10.3389/fpsyt.2022.1033816. Disponível em: https://www.frontiersin.org/articles/10.3389/fpsyt.2022.1033816/full. Acesso em: 30 jan. 2023
Resumo:	Introduction: The understanding of biological responses to psychedelics with antidepressant potential is imperative. Here we report how a set of acute parameters, namely emotional (depressive symptoms), cognitive (psychedelic experience), and physiological (salivary cortisol), recorded during an ayahuasca dosing session, modulated serum brain-derived neurotrophic factor (BDNF), serum cortisol (SC), serum interleukin 6 (IL-6), plasma C-reactive protein (CRP), and salivary cortisol awakening response (CAR). Methods: Results were analyzed 2 days after the psychedelic intervention (ayahuasca) versus placebo in both patients with treatment-resistant depression and healthy volunteers. These measures were assessed as part of a randomized double-blinded, placebo-controlled trial (n = 72). Results: Results revealed that larger reductions of depressive symptoms during the dosing session significantly moderated higher levels of SC in patients. Whereas lesser changes in salivary cortisol levels during the ayahuasca intervention were related to higher BDNF levels in patients with a larger clinical response in the reduction in depressive symptoms. No moderator was found for patient's CAR, IL-6, and CRP responses to ayahuasca and for all biomarker responses to ayahuasca in healthy controls and in the placebo group. Discussion: In summary, some specific emotional and physiological parameters during experimental ayahuasca session were revealed as critical moderators of the improvement of major depression biomarkers, mainly BDNF and SC two days after ayahuasca intake. These findings contribute to paving the way for future studies investigating the biological antidepressant response to psychedelic therapy
URI:	https://repositorio.ufrn.br/handle/123456789/51078
Aparece nas coleções:	ICe - Artigos publicados em periódicos

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