Martins, Rand RandallPedrosa, Nathália Beatriz de Oliveira2025-01-102025-01-102024-12-16PEDROSA, Nathália Beatriz de Oliveira. Interações medicamentosas potencialmente relacionadas à nefrotoxicidade em neonatos críticos. Orientador: Rand Randall Martins. 2024. 26 f. Trabalho de Conclusão de Curso (Graduação em Farmácia) - Departamento de Farmácia, Universidade Federal do Rio Grande do Norte, Natal, 2025.https://repositorio.ufrn.br/handle/123456789/61114Introduction: Nephrotoxicity is a concerning complication both in the short and long term due to the risk of developing acute kidney injury (AKI). Neonates in intensive care are patients with unique physiological characteristics that favor the occurrence of drug interactions and adverse drug interactions, including nephrotoxicity. Objective: This study aims to analyze drug interactions (DIs) potentially related to nephrotoxicity in critically ill neonates, identifying the drugs involved and their impact on renal function. Methods: A prospective cohort study was conducted between March 2023 and March 2024 in the Neonatal Intensive Care Unit (NICU) of a reference maternity hospital for high-risk pregnancies in Natal, Brazil. Patients were monitored daily, and daily averages of clinical and laboratory parameters were collected. This study was approved by the Ethics and Research Committee of the Januário Cicco Maternity School. Results: Among the 365 neonates enrolled in the study, 69.9% experienced one or more drug interactions during their NICU stay, 18.4% of which were potentially related to nephrotoxicity and occurred on average on the 14th day of hospitalization. The incidence rate of drug interactions potentially related to nephrotoxicity was 5.8 DIs per 100 neonate-days (4.55; 95% CI: 3.91). Most nephrotoxic interactions involved combinations of Furosemide — Fentanyl, Furosemide — Amikacin, and Furosemide — Cefepime. Neonatal patients exposed to potentially nephrotoxic DIs showed reduced creatinine clearance values (14.4 vs. 25.8 ml/min/1.73m²) and urine output (4 vs. 4.4 ml/kg/h), along with higher urea levels (52.9 vs. 27.6 mg/dL) compared to those not exposed. Conclusion: Certain drug interactions contribute to nephrotoxicity in neonates, emphasizing the importance of monitoring simple laboratory parameters to optimize healthcare team performance. Keywords: Drug interactions; Nephrotoxicity; Neonates; Intensive careAttribution-NonCommercial-NoDerivs 3.0 Brazilhttp://creativecommons.org/licenses/by-nc-nd/3.0/br/Interações medicamentosasNefrotoxicidadeNeonatosTerapia intensivabachelorThesisCNPQ::CIENCIAS DA SAUDE