Rêgo, Amália Cínthia Meneses doAraújo Filho, IramiAzevedo, Ítalo MedeirosJácome, Daniel TôrresRamalho, Rachel de Alcântara OliveiraMedeiros, Aldo Cunha2013-09-302013-09-302010RÊGO, Amália Cínthia Meneses do ; ARAÚJO FILHO, Irami ; AZEVEDO, Ítalo Medeiros ; JÁCOME, Daniel Tôrres ; RAMALHO, Rachel de Alcântara Oliveira ; MEDEIROS, Aldo Cunha. Biodistribution of technetium-99m pertechnetate after Roux-en-Y gastric bypass (Capella technique) in rats. Acta Cirurgica Brasileira, v. 25, p. 9-12, 2010. Disponível em:<http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0102-86502010000100004> Acesso em: 25 set. 2013.1678-2674https://repositorio.ufrn.br/jspui/handle/1/6287The biodistribution of sodium pertechnetate, the most used radiopharmaceutical in nuclear medicine, has not been studied in details after bariatric surgery. The objective was to investigate the effect of Roux-en-Y gastric bypass (RYGB) on biodistribution of sodium pertechnetate (Na99mTc-) in organs and tissues of rats. Methods: Twelve rats were randomly divided into two groups of 6 animals each. The RYGB group rats were submitted to the Roux-en-Y gastric bypass and the control group rats were not operated. After 15 days, all rats were injected with 0.1mL of Na99mTc- via orbital plexus with average radioactivity of 0.66 MBq. After 30 minutes, liver, stomach, thyroid, heart, lung, kidney and femur samples were harvested, weighed and percentage of radioactivity per gram (%ATI/g) of each organ was determined by gama counter Wizard Perkin-Elmer. We applied the Student t test for statistical analysis, considering p<0.05 as significant. Results: Significant reduction in mean %ATI/g was observed in the liver, stomach and femur in the RYGB group animals, compared with the control group rats (p<0.05). In other organs no significant difference in %ATI/g was observed between the two groups. Conclusion: This work contributes to the knowledge that the bariatric surgery RYGB modifies the pattern of biodistribution of Na99mTcengAcesso AbertoBiological AvailabilityBariatric SurgerySodium Pertechnetate Tc 99mRadiopharmaceuticalsRatsarticle