Fregonezi, Guilherme Augusto de FreitasBernardes Neto, Saint Clair Gomes2021-04-162020-11-30BERNARDES NETO, Saint Clair Gomes. Avaliação de tecnologia em saúde e desenvolvimento de inovação tecnológica para avaliação e monitoramento respiratório. 2020. 89f. Tese (Doutorado em Biotecnologia) - Centro de Tecnologia, Universidade Federal do Rio Grande do Norte, Natal, 2020.https://repositorio.ufrn.br/handle/123456789/32252Introduction: Health Technology Assessment (HTA) is defined as a set of research methods responsible for the continuous process of systematic assessment of the outcomes generated by the use of technology provided, in order to generate scientific evidence for clinical and political decisions. The treatment of patients with respiratory failure can be done through the use of mechanical ventilation (MV), and the transition process to return to spontaneous breathing is a point that needs new technologies seeking to ensure better conditions for the assessment and prediction of positive outcomes. Current assessment methods allow analysis of momentary indices that are unable to identify the evolution of the behavior of respiratory variables. Objectives: to develop technological innovation in the scope of respiratory assessment and monitoring, in addition to the development of evidence on the subject with systematic review. Results: scientific evidence on evaluation and respiratory monitoring of patients with neuromuscular disease weaning from MV was evidenced: (1) systematic review protocol entitled “Weaning from mechanical ventilation in people with neuromuscular disease: protocol for a systematic review; (2) submission of a scientific article entitled “Weaning from mechanical ventilation in people with neuromuscular diseases: systematic review”; in addition to (3) development and filing of an innovation patent entitled “Device for respiratory assessment and monitoring”. Conclusion: the device presented in the thesis, of an innovative character, allows continuous and detailed analysis of variables such as pressure, flow and volume, being able to identify early changes in the breathing pattern. Such a device will contribute to clinical applications in hospital, outpatient and home environments of patients on MV. The evidence from scientific evidence clarified the lack of an adequate protocol for assessing weaning conditions in patients with neuromuscular disease.Acesso AbertoBiotecnologiaDesmameSistema respiratórioVentilação mecânicadoctoralThesis