Campos, Julliane Tamara Araújo de MeloLopes, Rayssa Thainná Silva2022-03-042022-03-042022-02-14LOPES, Rayssa Thainná Silva. Carcinoma NUT: uma revisão clínica, histológica e genética. 2022. 52 f. Monografia (Graduação em Biomedicina) – Universidade Federal do Rio Grande do Norte, Natal, 2022.https://repositorio.ufrn.br/handle/123456789/46402Cancer is a disease characterized by the uncontrolled growth of cells in the body. Rare cancers have some aggravating factors in relation to the more common ones, such as the lack of in-depth clinical research. The present work deals about NUT carcinoma, a rare and aggressive neoplasm that was first reported in 1991. A literature search was carried out in order to describe the clinical, histological and genetic characteristics currently known about this carcinoma. All information was obtained from the literature available on the PubMed website, from which 27 articles were selected during the period from September 2021 to January 2022. It was observed that NUT carcinoma affects men and women without distinction, from children to the seniors, with higher frequency in young adults. The primary tumor appears mainly in the head or neck, but is also reported in other body sites, in addition, metastases and compromised lymph nodes are frequent. The initial symptoms are very nonspecific and imaging exams are essential for the discovery of the tumor mass. Histologically, small, poorly differentiated squamous cells are observed, with little cytoplasm, round nuclei, central nucleoli, necrosis, neutrophil infiltrate, mitosis, keratinization and areas of sudden squamous differentiation. The immunohistochemical test for NUT protein is the gold standard for the diagnosis of this neoplasm. Genetically, a fusion between two genes is found, forming the BRD4-NUT, BRD3-NUT and other less common variants. These fusions are known to recruit p300 and activate transcription of large stretches of active chromatin, called megadomains. The expression of some genes contained in these megadomains affects the development of cells and the filling of regulatory sites for the MYC and p63 genes is a strong explanatory indication for the high aggressiveness of this neoplasm.Attribution-NonCommercial-NoDerivs 3.0 Brazilhttp://creativecommons.org/licenses/by-nc-nd/3.0/br/Carcinoma NUTNeoplasia RaraBRD4-NUTBRD3-NUTNUT CarcinomaRare neoplasmBRD4-NUTBRD3-NUTbachelorThesis