Cavalcante, Jeferson de SouzaSilveira Junior, George Siqueira da2022-04-112022-05-252022-04-112022-05-252021-04-23SILVEIRA JUNIOR, George Siqueira. Associações entre disrupturas de ritmicidade circadiana e doenças neurodegenerativas.2021.32f. Trabalho de Conclusão de Curso (Graduação em Ciências Biológicas) – Centro de Biociências, Universidade Federal do Rio Grande do Norte, Natal,2021https://repositorio.ufrn.br/handle/123456789/47322Circadian rhythms are endogenous oscillations with a period of approximately 24 hours, these oscillations are manifested by all living beings. Circadian rhythms are related to many biological processes such as body temperature, hormonal excretion cycle, cell cycle regulation, feeding and rest and activity behavior, the suprachiasmatic nucleus is considered the main pacemaker in mammals and its molecular mechanisms are self-sustaining. cyclic, in a negative and positive feedback loop, formed by CLOCK and BMAL1 that activate the transcription of the Cry and Per genes. PER and CRY to inhibit the transcription that is mediated by CLOCK and BMAL1. Disruptions in this system can then have negative effects on many functions of the organism, such as, impair sleep quality, cognitive performance, mental health, metabolism and wakefulness, functions that also suffer from the effects of neurodegenerative diseases such as Parkinson's disease, Alzheimer's disease and Huntington's disease, in which different areas of the brain are affected, including the nuclei involved with the circadian timing system. Among the relationships reported in this review in Alzheimer's disease there are sleep fragmentation, increased wakefulness and accumulation of β-amyloid and others, in Parkinson's disease, sleep disorders such as insomnia, excessive daytime sleep and the relationship between dopamine and the retina as in the production of melanopsin, in Huntington's disease there are behavioral disorders of REM sleep, dysregulation in peripheral clocks and others. Therapies such as the use of melatonin and light therapies have shown to be positive and functional for circadian interventions in neurodegenerative diseases, more longitudinal studies are needed to better understand the relationship between neurodegenerative diseases and circadian disruptions.Attribution-NonCommercial-NoDerivs 3.0 Brazilhttp://creativecommons.org/licenses/by-nc-nd/3.0/br/Ritmos circadianos, Doença de Parkinson, Doença de Alzheimer, Doença de Huntington, Cronoterapia.Circadian rhythms, Parkinson's disease, Alzheimer's disease, Huntington's disease, Chronotherapy.bachelorThesis