Fernandes, Nedja SuelyDamasceno Junior, Elmar2018-04-192021-09-272018-04-192021-09-272017-12-14DAMASCENO JUNIOR, Elmar. Avaliação da liberação do ácido ascórbico em comprimidos de liberação prolongada através de testes de dissolução in vitro. 2017. 63f. Trabalho de Conclusão de Curso (Graduação em Química), Instituto de Química, Universidade Federal do Rio Grande do Norte, Natal, 2017.https://repositorio.ufrn.br/handle/123456789/38264The quality of drugs is a legal and moral attribute, and quality control is a crucial step in the development of pharmaceutical forms for commercialization. In vitro dissolution tests are an extremely important tool in the development and quality control of drugs, making it possible to evaluate the performance or efficiency of the pharmaceutical form in releasing the active substance through the amount dissolved in the dissolution medium when the product is subjected to specific equipment. In this sense, the main objective of the present study was to evaluate the release of ascorbic acid in prolonged release commercial vitamin C tablets by dissolution tests. Ascorbic acid (active principle) and drugs of two different brands (brand A and brand B) were characterized using the techniques of Molecular Absorption Spectroscopy in the Region of Infrared (IV), Thermogravimetry/Derived Thermogravimetry (TG/DTG) and Differential Scanning Calorimetry (DSC). The in vitro dissolution tests were performed in a dissolver with a paddle apparatus at a temperature of 37 ° C (± 0.5 ° C), employing 900 mL of ultrapure water as the dissolution medium and a stirring speed of 50 rpm. The ascorbic acid dissolved in the aliquots of dissolution media obtained during the tests was quantified using the UV-Vis Molecular Absorption Spectroscopy technique. From the dissolution profiles, it was observed that the formulations of both brands promoted a prolonged release of ascorbic acid. Brand-name drug A dissolved about 67% of the active ingredient in about 360 minutes. Brand-name drug B, however, dissolved about 72% at the same dissolution time. Release kinetics were evaluated using kinetic models such as order zero, first order and Higuchi. The model that best fit the experimental data was that of Higuchi.openAccessÁcido ascórbicoLiberação prolongadaDissoluçãoCinética de liberaçãobachelorThesis