Lima, João Paulo Matos SantosMedeiros, Matheus Anselmo2025-08-272025-08-272025-03-14MEDEIROS, Matheus Anselmo. Integrando dados gênicos: do desenvolvimento de uma plataforma de integração de polimorfismos de nucleotídeo único (SNPs) provenientes de painéis metabólicos ao papel da creatina na saúde renal. Orientador: Dr. João Paulo Matos Santos Lima. 2025. 84f. Tese (Doutorado em Bioinformática) - Instituto Metrópole Digital, Universidade Federal do Rio Grande do Norte, Natal, 2025.https://repositorio.ufrn.br/handle/123456789/65342The integration of genomic data into personalized nutrition has advanced significantly, providing new insights into the influence of single nucleotide polymorphisms (SNPs) on metabolic processes and responses to nutritional interventions. In this context, this thesis is structured into two parts. In the first part, a bioinformatics platform was developed to integrate SNPs related to genes involved in metabolic pathways associated with diseases, utilizing databases such as KEGG and GeneCards. The platform enables the mapping of SNPs to metabolic pathways, diseases, and global allele frequencies, consolidating essential information for understanding the genetic impact on various diseases. In the second part, the relationship between creatine supplementation and renal function was investigated based on gene expression analysis using databases such as GTEx and GEO. Genes such as SLC6A8, IGF1, and AKT1 were analyzed under different renal conditions, including nephrosclerosis, transplant rejection, and renal carcinomas. The results highlight the relevance of bioinformatics in interpreting data available in biological databases, emphasizing the need for integration and analysis tools to enable healthcare professionals to access this information and support clinical decisions with greater precision.pt-BRAcesso AbertoCreatinaGenômicaSNPsBioinformáticaNutrição personalizadadoctoralThesisCIENCIAS BIOLOGICAS