Martins, Rand RandallFonseca, Andreia Suelle Moura2025-05-282025-05-282023-10-25FONSECA, Andreia Suelle Moura. Ferramenta gatilho para a otimização do seguimento farmacoterapêutico em gestantes de alto risco: desenvolvimento e validação. Orientador: Dr. Rand Randall Martins. 2023. 57f. Dissertação (Mestrado em Ciências Aplicadas à Saúde da Mulher) - Centro de Ciências da Saúde, Universidade Federal do Rio Grande do Norte, Natal, 2023.https://repositorio.ufrn.br/handle/123456789/63726Introduction: Clinical pharmacy is the area of pharmacy concerned with the science and practice of rational drug use, in which pharmacists provide patient care to optimize pharmacotherapy, promote health and well-being, and prevent disease using strategies and tools for this purpose. However, as far as we know, there are no behavioral trigger tools for the detection of Drug-Related Problems in hospitalized pregnant women. Objective: to develop and validate a trigger tool to optimize the identification of Drug-Related Problems in hospitalized high-risk pregnant women. Methods: observational, prospective, descriptive and longitudinal study, developed in a Brazilian maternity hospital from September 2019 to July 2022. Based on the profile and frequency of prescription, the main parameters for monitoring effectiveness and safety were used to develop a triggers. The trigger tool was validated with a sample of 150 pregnant women evaluated concurrently using the SOAP method in two groups: test group (only applied the SOAP method if at least one positive trigger) and standard group (all patients evaluated). The investigation involved identification and characterization of Drug-Related Problems via PCNE v. 9.0. The tool was characterized in terms of accuracy, sensitivity, specificity and predictive values, in addition to using the Brier method for validation. Results: The trigger tool showed a sensitivity of 74.1% (CI95% 67.7 - 81.1), specificity of 70.7% (CI95%63.4 - 78.0) and accuracy of 73.2% (CI95% 65.3 - 79.7). Internal validation showed a Brier score of 0.269. Conclusion: The evaluated tool showed a moderate sensitivity and an acceptable positive predictive value, making it a useful tool in the initial screening and identification of possible Drug-Related Problems in hospitalized high-risk pregnant women.pt-BRAcesso AbertoSeguimento farmacoterapêuticoGestação de alto riscoProblemas relacionados a medicamentosGatilhomasterThesisCIENCIAS DA SAUDE