Lima, Lucimar Fernandes de2018-03-192018-03-192017-11-17LIMA, Lucimar Fernandes de. Gel de biopolímero para tratamento da pediculose. 2017. 96f. Dissertação (Mestrado Profissional em Ciência, Tecnologia e Inovação) - Escola de Ciência e Tecnologia, Universidade Federal do Rio Grande do Norte, Natal, 2017.https://repositorio.ufrn.br/jspui/handle/123456789/24913Pediculosis is characterized by infestation by Pediculus humanus capitis in humans. Since 1963 pediculosis has been growing significantly, mainly in the school environment and in urban centers. This is due to the agglomeration of people, given the ease with which it is transmitted. The current therapeutic procedures present side effects, offering a risk to the health of the host and contributing to the resistance of the parasite to the drugs used, increasing costs with the treatment. The authors set out to develop an alternative, non-toxic, biocompatible, biodegradable product that would undermine the genetic mutation presented by lice to currently available treatments, all supported in the management of innovation. To manage the project, samples of the hydrogel - chitosan dispersion in aqueous solution of acetic acid were prepared with previous dissolution of methylparaben and addition of essence and glycerine - for later use in the in vitro test and physicochemical characterization of the product. The physico-chemical characterization of the samples was performed through organoleptic analysis, rheological analysis and pH measurement. The methodological validation of the product was performed through the in vitro test, which involved sample selection, collection and standardization of hair strands, examination and classification of pediculosis and, finally, application and verification of product efficiency. The cost management was carried out from the calculations of fixed and variable costs, necessary for the production of the hydrogel. The filing of the patent application was filed with the National Institute of Industrial Property (INPI) under registry number BR 1020150251793 to guarantee the right to intellectual property on the product. The results obtained during the physico-chemical characterization of the hydrogel revealed staining and odor stability during the 60 days in which the hydrogel was stored. It was observed in the rheological study the characteristic behavior of pseudoplastic fluids of the prepared chitosan dispersions, due to the observed reduction in viscosity as a function of the elevation of the shear rate. The percentage of egg removal in the hydrogel treated sample was higher (83% of the eggs in the first application) than that observed in the application of acetic acid solution (32%). The treatment using the proposed product, called hydrogel, can be made available at a competitive price, given the average prices of concurrents.Acesso AbertoGestão da inovaçãoValidação metodológicaPediculoseQuitosanamasterThesisCNPQ::ENGENHARIAS: CIÊNCIA, TECNOLOGIA E INOVAÇÃO