Fayh, Ana Paula TrussardiSouza, Ana Priscilla Silva de2020-09-112020-09-112020-04-01SOUZA, Ana Priscilla Silva de. Efeitos da intervenção dietética sobre a qualidade de vida e a toxicidade derivada da quimioterapia neoadjuvante em mulheres com câncer de mama: ensaio clínico randomizado. 2020. 77f. Dissertação (Mestrado em Nutrição) - Centro de Ciências da Saúde, Universidade Federal do Rio Grande do Norte, Natal, 2020.https://repositorio.ufrn.br/jspui/handle/123456789/30036Breast cancer is a chronic disease of multifactorial etiology, with an increasing worldwide incidence and with high mortality rates. Among the factors associated with lifestyle, healthy eating is of great relevance not only in prevention, but also during the treatment of this type of cancer. The reduction of toxicities, improved quality of life, better prognosis and increased survival may be reflections of healthy eating practices during cancer therapy. In this sense, the present study aimed to evaluate the effects of a nutritional and dietary intervention on the quality of life and toxicities of women with breast cancer who start neoadjuvant chemotherapy. For this, a randomized clinical trial was carried out with female patients diagnosed with breast cancer who started neoadjuvant chemotherapy treatment from November 2018 to December 2019, at the Advanced Oncology Center (CECAN), of the North Riograndense League Against Cancer, located in Natal / RN, Brazil. The volunteers were randomized and allocated to parallel groups, where the control (CG) and intervention (GI) groups received nutritional advice on healthy eating practices during treatment and, in addition, only the intervention group received an individualized diet plan. The two groups were followed during the first three cycles of chemotherapy, moments in which nutritional, anthropometric, muscle strength, quality of life assessments were performed, using the QLQ C-30 questionnaire from the European Organization for Research and Treatment of Cancer (EORTC), and toxicities, according to the Common Terminology Criteria for Adverse Events (CTCAE) classification. The Chi-square and Fisher's exact tests were used to compare the proportions between groups. With the t test for paired samples anthropometric and strength data were compared between groups, at the beginning and at the end of the study. The generalized estimation equation was used to verify the effect of group and time interaction on the selected variables. Thirty four women were followed up, 15 of whom were allocated to the CG and 19 to the IG, with an average age of 45.5 ± 8.6 and 44.3 ± 9.2 years, respectively in each group. Throughout the study, the CG significantly reduced its handgrip strength, while the IG preserved this measure (P = 0.009). Although no significant differences were observed between groups in relation to global health / QOL, within the functional scales, the job function showed a decline in the CG (P <0.001 for interaction). Also on the EORTC - QLQ-C30 symptom scales, the GI showed less nausea / vomiting (P <0.001 for interaction) and loss of appetite (P <0.001 for time). Regarding toxicities, the GI also had a lower frequency of leukopenia in the third cycle of chemotherapy (P = 0.034) and a lower frequency of abdominal pain in the second cycle of treatment (P = 0.034) when compared to the CG. In conclusion, the results indicate that the dietary intervention preserves a domain of quality of life related to work function, produces reflexes in the occurrence of nausea / vomiting and loss of appetite, which may reduce the frequency of leukopenia and abdominal pain during neoadjuvant chemotherapy treatment.Acesso AbertoCarcinoma de mamaDieta e quimiotratamentomasterThesis