Mendonça, Karla Morganna Pereira Pinto deMonteiro, Karolinne Souza2019-08-202019-07-09MONTEIRO, Karolinne Souza. Estudo da fibrose cística: efeitos de um programa de treinamento intervalado de alta intensidade sobre desfechos clínicos e qualidade de vida e validação de um instrumento de avaliação do conhecimento sobre a doença. 2019. 269f. Tese (Doutorado em Fisioterapia) - Centro de Ciências da Saúde, Universidade Federal do Rio Grande do Norte, Natal, 2019.https://repositorio.ufrn.br/jspui/handle/123456789/27587Study 1: Effects of high-intensity interval program on glucose tolerance in children and adolescents with cystic fibrosis: a randomized controlled trial. Aim: To verify the effects of high intensity interval training on the glucose tolerance and other health outcomes of children and adolescents with cystic fibrosis. Methodology: Controlled, randomized and blinded clinical trial, performed from June/2018 to June/2019, at the Child and Adolescent Unit of the University Hospital Onofre Lopes, Natal-RN. There were included 10 individuals, male and female, diagnosed with CF, from 6 to 18 years old. They were allocated and randomized into blocks: control group (CG) and experimental group (EG). Both received educational intervention and the EG performed high intensity interval training 3x/week for 8 weeks at home. The primary outcome was glucose tolerance. The secondary outcomes were pulmonary function, respiratory muscle strength, exercise tolerance, quality of life, and exacerbations. Results: There was no intragroup control and intergroup difference of all outcomes. There was a difference between the pre and follow-up evaluations only of the area under the curve of the glucose (p = 0.04) intragroup experimental. Conclusion: High intensity interval training was not able to increase glucose tolerance and other health outcomes in children and adolescents aged 6 to 18 years with CF. Study 2: Translation, cross-cultural adaptation and psychometric evaluation of the Brazilian version of the Cystic Fibrosis Knowledge Scale (CFKS) Aim: To translate, cross-culturally adapt and analyze the psychometric properties of the Cystic Fibrosis Knowledge Scale (CFKS). Methodology: Exploratory and psychometric methodological study that involved translation, cross-cultural adaptation and evaluation of the following psychometric properties: reliability, viability, construct, predictive, concurrent and discriminant validity. Results: The Brazilian version of CFKS showed high internal consistency (α = 0.91), moderate floor and ceiling effects, with no differences in test-retest scores. The results of the Kaiser-Meyer-Olkin test (KMO = 0.93) and the Barlett sphericity test (χ² = 3737.54; p = 0.00) indicated an adequate adjustment of the data, allowing the exploratory factorial analysis. Factorial exploration identified three dimensions: "medicinal, physiotherapeutic and social interaction aspects", "gastrointestinal, genetic and reproductive aspects", and "nutritional aspects". There was good predictive validity, with a difference in the scores of the Brazilian version of the CFKS among all the evaluated groups (p <0.001), good discriminant validity, since individuals with asthma had greater knowledge of asthma compared to CF (r = 0.401, p = 0.005). However, there was no difference between the time of diagnosis and knowledge on CF (r = -0.25, p = 0.11) neither between treatment adherence and knowledge on CF (r = -0.04; p = 0.77). Conclusion: The translation, cross-cultural adaptation and evaluation of the psychometric properties of the Brazilian version of the CFKS indicated that the scale is able to provide valid, reliable and reproducible measures in the evaluation of the knowledge about CF.Acesso AbertoFibrose císticaIntolerância à glicoseTreinamento intervalado de alta intensidadeEstudos de validaçãoConhecimentodoctoralThesisCNPQ::CIENCIAS DA SAUDE::FISIOTERAPIA E TERAPIA OCUPACIONAL