Souto, Janeusa Trindade deGomez, Lucas Alves de Sousa2024-08-092024-08-092024-02-29GOMEZ, Lucas Alves de Sousa. Papel da Vitamina D e de marcadores inflamatórios em pacientes internados em UTIs durante diferentes picos pandêmicos do SARS-CoV-2. Orientadora: Dra. Janeusa Trindade de Souto. 2024. 83f. Dissertação (Mestrado em Biologia Parasitária) - Centro de Biociências, Universidade Federal do Rio Grande do Norte, Natal, 2024.https://repositorio.ufrn.br/handle/123456789/59114The prognosis of covid-19 relies on several factors, including patient's immune response, metabolic and nutritional status and genetic characteristics of the virus. This study investigated the inflammatory profile, oxidative stress and vitamin D levels in patients admitted to intensive care units at Hospital do Coração (HC) and Hospital Giselda Trigueiro (HGT), possibly infected with the B.1.1.33 strain (2020) and P.2 or P.1 (Gamma) strains of SARS-CoV-2, respectively. Patients with positive RT-PCR were organized into two groups: the first group had their blood collected from April to May 2020 (B.1.1.33). The second group had blood collected in January and February of 2021 (P.2/P.1). We determined global and differential leukocyte counts, neutrophillymphocyte ratio (NLR), platelet-lymphocyte ratio (PLR), systemic levels of C-reactive protein (CRP), lactic dehydrogenase (LDH), creatinine, vitamin D, malondialdehyde (MDA), cytokines and chemokines. Based on hematological characteristics and blood marker levels, they were characterized by two different groups, observing that patients with P.2/P.1 (group 2) had a higher number of leukocytes, mainly neutrophils, with higher proportions of NLR and PLR when compared to patients B.1.1.33 (group 1 – G1). Furthermore, higher levels of LDH, CXCL8 and MDA and lower levels of vitamin D, GM-CSF and IFN- were found in G2 patients. The neutrophilia observed together with elevated levels of CXCL8 and LDH in G2 patients suggests greater susceptibility to the occurrence of pyroptosis and NETosis, which may play an important role in the severity of lung damage and systemic compromise during Covid-19 caused by the P.2 and P.1 lineages, in contrast to patients with a more ancestral lineage of the virus.Acesso AbertoInflamaçãoCovid-19Vitamina DmasterThesisCNPQ::CIENCIAS BIOLOGICAS