Medeiros, Aldo da CunhaCarvalho, Marilia Daniela Ferreira de2014-12-172013-04-262014-12-172012-10-30CARVALHO, Marilia Daniela Ferreira de. Consequências da colectomia associada à hepatectomia no metabolismo hepático e na forma e função de hemácias em ratos. 2012. 137 f. Dissertação (Mestrado em Ciências da Saúde) - Universidade Federal do Rio Grande do Norte, Natal, 2012.https://repositorio.ufrn.br/jspui/handle/123456789/13395This study investigated the influence of partial colectomy associated with hepatectomy on the biodistribution of the 99mTc-phytate, on metabolic parameters, as well as labeling and morphology of red blood cells. Wistar rats were distributed into three groups (each with 6), nominated as colectomy, colectomy+hepatectomy and sham. In the 30th postoperative day all rats were injected with 99mTc-phytate 0.1mL i.v. (radioactivity 0.66 MBq). After 15 minutes, liver sample was harvested and weighed. Percentage radioactivity per gram of tissue (%ATI/g) was determined using an automatic gamma-counter. Serum AST, ALT, alkaline phosphatase and red blood cells labeling were determined. The liver %ATI/g and red blood cells labeling were lower in colectomy and colectomy+hepatectomy rats than in sham rats (p <0.05), and no difference was detected comparing the colectomy and colectomy+hepatectomy groups. Red blood cells morphology did not differ among groups. Serum levels of AST, ALT and alkaline fosfatase were significantly higher in colectomy+hepatectomy than in colectomy rats (p<0.001). Hepatectomy associated with colectomy lowered the uptake of radiopharmaceutical in liver and in red blood cells in rats, coinciding with changes in liver enzymatic activityapplication/pdfAcesso AbertoColectomia. Hepatectomia. Metabolismo. Biodisponibilidade. RadiofármacoColectomy. Hepatectomy. Metabolism. Biological availability. RadiopharmaceuticalmasterThesisCNPQ::CIENCIAS DA SAUDE