Dourado Junior, Mário Emílio TeixeiraFregonezi, GuilhermeAraújo, Paloma Russelly SaldanhaMacêdo, Tathiana Lindemberg FerreiraResqueti, Vanessa RegianeAndrade, Armele de Fátima Dornelas de2023-07-282023-07-282013-03FREGONEZI, Guilherme; ARAUJO, Palomma Russelly Saldanha; MACÊDO, Tathiana Lindemberg Ferreira; DOURADO JUNIOR, Mario Emilio Teixeira; RESQUETI, Vanessa Regiane; ANDRADE, Armele de Fátima Dornelas de. Monitoring respiratory muscle strength assists in early diagnosis of respiratory dysfunction as opposed to the isolated use of pulmonary function evaluation in amyotrophic lateral sclerosis. Arquivos de Neuro-Psiquiatria, [S.L.], v. 71, n. 3, p. 146-152, mar. 2013. FapUNIFESP (SciELO). http://dx.doi.org/10.1590/s0004-282x2013000300004. Disponível em: https://www.scielo.br/j/anp/a/mCzGFQcrXrfMwvvH6VVqS7y/?lang=en. Acesso em: 24 jul. 2023.https://repositorio.ufrn.br/handle/123456789/54257Objective: It was study the relationship between respiratory muscle strength and forced vital capacity (FVC) in patients with amyotrophic lateral sclerosis (ALS) versus healthy subjects. Methods: Pulmonary function and respiratory muscle strength [maximal inspiratory (PImax), maximal expiratory (PEmax) and sniff nasal inspiratory pressure (SNIP)] were assessed in patients with ALS and healthy subjects, matched using cutoffs established in the literature for impaired pulmonary function and respiratory muscle weakness. Results: Twenty-eight ALS patients and 28 healthy subjects were studied. We found sensitivity and specificity for PImax, PEmax and SNIP of 75/58%, 81/67% and 75/67%. The Receiver Operating Characteristic curve (ROC curve) indicated that the variables PImax, PEmax and SNIP can identify differences in respiratory muscle strength between ALS and healthy individuals at 0.89, 0.9 and 0.82, respectively. A positive correlation was recorded between FVC (%) versus SNIP, PImax and PEmax. Conclusion: In ALS, monitoring respiratory muscle strength assists in early diagnosis of respiratory dysfunction as opposed to the isolated use of FVC.Attribution-NonCommercial 3.0 Brazilhttp://creativecommons.org/licenses/by-nc/3.0/br/debilidade musculardoenças neuromuscularesteste de função pulmonarmúsculos respiratóriosmuscle weaknessrespiratory musclesneuromuscular diseasespulmonary function testMonitoring respiratory muscle strength assists in early diagnosis of respiratory dysfunction as opposed to the isolated use of pulmonary function evaluation in amyotrophic lateral sclerosisMonitoramento da força muscular respiratória em detrimento do uso isolado da avaliação da função pulmonar para o diagnóstico precoce de disfunção respiratória em pacientes com esclerose lateral amiotróficaarticlehttps://doi.org/10.1590/S0004-282X2013000300004