Lima, Gustavo Zampier dos SantosSousa, Matheus Phellipe Brasil de2023-11-072023-11-072023-09-22SOUSA, Matheus Phellipe Brasil de. Influência da temperatura no acoplamento efático neuronal via modelo de Hodgkin-Huxley. Orientador: Dr. Gustavo Zampier dos Santos Lima. 2023. 141f. Dissertação (Mestrado em Física) - Centro de Ciências Exatas e da Terra, Universidade Federal do Rio Grande do Norte, Natal, 2023.https://repositorio.ufrn.br/handle/123456789/55201Several studies have already shown the importance of synaptic, chemical or electrical, communication in maintaining various biological functions in the human body, as well as its sensitivity to temperature variations. In addition, to neuronal communication, there is another type of communication, called ephaptic communication. Ephaptic communication arises from electrical fields generated by a neuron or neuron population. This communication, which is still little explored, has been gaining prominence because several hypotheses have been raised about its biological function. Therefore, this work aims to introduce the ephaptic entrainment term into the Hodgkin and Huxley model, as well as the term responsible for temperature variation in the model. The results of this work were compared with empirical results and results obtained via hybrid model simulation. To obtain the results, we varied the temperature in a symmetrical interval, around 0 oC, and separated the neuronal activity into two regimes: Subthreshold and Suprathreshold. To analyse the subthreshold results, we used circular statistics to evaluate the phase differences between the neuronal potential and the external ephaptic signal. In the suprathreshold regime, we used the Inter-Spike Interval (ISI) to evaluate the model’s firing frequency, the Population Vector to obtain the phase preferences between the neuronal potential and the ephaptic signal, and we ended by using Spike Field Coherence (SFC) to measure the synchronization between the signals. The results obtained in this work, by simulating the adapted Hodgkin and Huxley model, not only resemble the results in the literature, but also show that temperature can influence ephaptic entrainment.Acesso AbertoFísicaArrastamento efáticoComunicação efáticaModelo de HodgkinHuxleyTemperaturamasterThesisCNPQ::CIENCIAS EXATAS E DA TERRA::FISICA