Ferrari, MarcioRodrigues, Rayllan de Oliveira2017-02-142017-02-142016-01-26RODRIGUES, Rayllan de Oliveira. Desenvolvimento de emulsões contendo extrato de Kalanchoe brasiliensis Cambess e avaliação clínica da eficácia hidratante. 2016. 92f. Dissertação (Mestrado em Ciências Farmacêuticas) - Centro de Ciências da Saúde, Universidade Federal do Rio Grande do Norte, Natal, 2016.https://repositorio.ufrn.br/jspui/handle/123456789/21990Kalanchoe brasiliensis Cambess specie, belonging to the Crassulaceae family, presents flavonoids, polysaccharides and ascorbic acid in its chemical composition. These compounds are generally used in cosmetics formulations as antioxidants, moisturizers and anti-aging properties. This research aimed to development moisturizing emulsions add or not with hydroethanolic extract of the Kalanchoe brasiliensis leaves and evaluated its moisturizing clinical efficacy. Formulations have been developed with different concentrations of Sodium Acrylates/ Beheneth-25 Methacrylate Crosspolymer (and) Hydrogenated Polydecene (and) Lauryl Glucoside (Novemer™EC-2 polymer), incorporated to Acrylates/C10-30 Alkyl Acrylate Crosspolymer (Carbopol® Ultrez-20). The formulations were added or not with plant extract 0.5% (w/w) and subjected to accelerated stability tests. In accelerated stability study, the samples were stored at different temperatures for 90 days. The organoleptic characteristics, pH and rheological behavior were evaluated. The formulation containing 3.0% Novemer™EC-2 and 0.4% Carbopol® Ultrez-20 added with hydroethanolic extract of K. brasiliensis 0.5% was considered stable. Moisturizing clinical efficacy was evaluated by capacitance and transepidermal water loss methodologies. The formulation containing extract compared to vehicle promoted increase significantly statistical of the water content of the stractum corneum and decrease of transepidermal water loss, promoting barrier effect until five hours after single application of the formulation. The emulsion developed with 0.5% of hydroethanolic extract of K. brasiliensis leaves presented moisturizing efficacy acting possibly by occlusion and humectation mechanisms, demonstrating potential use as a moisturizing cosmetic product.Acesso AbertoCaatingaCosméticosEstabilidadeKalanchoe brasiliensismasterThesisCNPQ::CIENCIAS DA SAUDE::FARMACIA