Andrade Neto, Valter Ferreira deSalzer, Ana Luíza Franco2019-06-262021-10-062019-06-262021-10-062019-06-07SALZER, Ana Luíza Franco. Avaliação In Vitro da atividade antiplasmódica das lignanas em modelo de Plasmodium falciparum. 2019. 30f. Trabalho de Conclusão de Curso (Graduação em Biomedicina) - Centro de Biociências, Universidade Federal do Rio Grande do Norte, Natal, 2019.https://repositorio.ufrn.br/handle/123456789/43203Malaria is an infectious, vector-borne disease caused by protozoa of the genus Plasmodium and characterized by high fever, chills, headache, hemolytic anemia, and jaundice. With the aggravation of the clinical picture and absence of treatment, malaria can evolve to its most severe form, causing systemic and cerebral damages, causing high morbidity and mortality. In Brazil, the majority of cases of malaria are found in the north of the country (Amazon region), where the climate favors the reproduction of the transmitting mosquito and the survival of the protozoan. However, in states of the extra-Amazon region, the occurrence of imported malaria is a major concern due to high rates of lethality and risk of outbreaks. The species of clinical and scientific interest that cause human malaria are Plasmodium falciparum, Plasmodium vivax, Plasmodium malariae, Plasmodium ovale, Plasmodium knowlesi and Plasmodium simium. Drug treatment is still the main strategy for malaria control; however, P. falciparum has acquired resistance to the usual antimalarials much more rapidly than the development and implementation of new drugs used against malaria; one of WHO's priorities is the development of new antimalarials that are effective, inexpensive and have new targets. The aim of the present work was to evaluate in vitro the antiplasmodic activity of Lignans against the asexual intra - erythrocytic stage of Plasmodium falciparum (strain 3D7) and observed an expressive reduction in the growth of the culture treated with the compound. LIG-C1, LIG-C2 and LIG-E1 were the ones that had the best inhibition of Plasmodium falciparum growth.Malária, Plasmodium falciparum, Lignana, Atividade antimalárica.Malária, Plasmodium falciparum, Lignana, Antimalarial activity.bachelorThesis