SILVA, Francisco Ordelei Nascimento daNobre, Marcelly de Sousa2025-07-082025-07-082025-06-18NOBRE, Marcelly de Sousa. SÍNTESE E CARACTERIZAÇÃO DO COMPLEXO CIS-[RU(BPY)(FEN)(2- AMINO)(NO)](PF6)3. Orientador: Francisco Ordelei Nascimento da Silva.2025. 62 f. Trabalho de Conclusão de Curso (Graduação) - Curso de Bacharelado em Química, Universidade Federal do Rio Grande do Norte, Natal, RN, 2025.https://repositorio.ufrn.br/handle/123456789/64164Nitric oxide (NO) is a biologically active molecule that plays an essential role in several physiological processes, such as vasodilation, neurotransmission and immune response. The search for systems that enable its controlled release has driven the development of metal complexes, among which ruthenium nitrosyl complexes stand out for their stability, low toxicity and ability to release NO under chemical, electrochemical or photochemical stimuli. In this context, this work aimed to synthesize, characterize and study the reactivity of the cis-[Ru(bpy)(phen)(2-amino)(NO)](PF6)3 complex, using the 2-aminobenzothiazole ligand, aiming at its potential application as a controlled nitric oxide donor. The nitrosyl complex was obtained by reacting the precursor cis-[Ru(bpy)(phen)Cl2] with 2-aminobenzothiazole and then with the addition of sodium nitrite and trifluoroacetic acid in ethanol/water under stirring. Through electronic spectroscopy in methanol, it was possible to observe intraligand transitions of the bipyridine and phenanthroline ligands, in addition to charge transfer bands from the metal center to the polypyridine ligands at 411 nm and to the NO ligand, close to 454 nm. In the infrared vibrational spectrum, in ATR crystal, the stretching of NO+ was observed at high frequencies at 1932 cm-1 , indicating the coordination of nitric oxide to the metal center. In addition, electrochemical studies, through the cyclic voltammogram, confirmed the presence of a quasi-reversible redox process associated with the NO⁺/NO⁰ pair with E₁/₂ = 178 mV. The data obtained by square wave voltammetry and by photochemical study under white light indicate that the release of nitric oxide occurs through a chemical process, where the reduction of the NO⁺ ligand to NO⁰ weakens the bond with ruthenium (Ru²⁺), favoring the exit of NO and allowing the subsequent coordination of a water molecule.pt-BRQuímicaBioinorgânicaRutênio2-AminobenzotiazolÓxido NítricobachelorThesis