Chavante, Suely FerreiraLira, Mirella Cunha2018-12-182021-10-062018-12-182021-10-062018-11-29LIRA, Mirella Cunha. Resíduos da carcinicultura como fonte de glicosaminoglicanos com potencial terapêutico. 2018. 32 f. Trabalho de conclusão de curso (Graduação em Biomedicina) – Curso de Biomedicina, Centro de Biociências, Universidade Federal do Rio Grande do Norte, Natal, 2009.https://repositorio.ufrn.br/handle/123456789/43179An important class of sulfated polysaccharides, the glycosaminoglycans(GAGs), possesses a remarkable role as signalling biomolecules. Complexes compositions and structural arranges grants them a wide capacity of interacting with biological componentes and, then, modulate importante events such as haemostasis and imunological response. Its adaptative relevance is so evident that reflects on the manteinance of molecules of this nature in the Animal Kingdon through Evolution. Because of the extense variability not only structural but also functional of this compounds, despite all the studies realized there’s, yet, so much to explore and elucidate of its synthesis, structure and bioactivity. Among GAGs, the most studied, tough, most representative is heparin. Initially used as anticoagulante/antithrombotic, it presented, later, other insteresting and expressive therapeutic potencials, for example, antitumoral and anti-inflammatory. On the other hand of its extraordinary therapeutic eficcacy, cotaminated lots and incovenient hemorhaegic complications, limits its administration. Under such perspective, the search for molecules capable of mimetize its pharmacological properties, but present reduced adverse effects grown up. In this context, it was noticed the occourence of GAGs in the cephalotorax of the shrimp L. vannamei, na industrial subproduct. This way, interesting models for a sustentability way for developing new therapeutic approuches. From this shrimp, is possible to isolate compounds heparin-like, two different types of condroitin-like such as a hybrid of heparin/heparan sulfate. The study of its structural features and bioactivities consolidate therapeutic potencials already described in literature and suggest others still to explore. This study aims to discuss the structural features and therapeutic potencials of shrimp compounds.Attribution-NonCommercial-ShareAlike 3.0 Brazilhttp://creativecommons.org/licenses/by-nc-sa/3.0/br/GlycosaminoglycansReutilizationLitopenaeus vannameiTherapeutic modelsGlicosaminoglicanosReaproveitamentoLitopenaeus vannameiModelos terapêuticosbachelorThesis