Fayh, Ana Paula TrussardiFerreira, Gláucia Mardrini Cassiano2024-11-052024-11-052024-08-23FERREIRA, Gláucia Mardrini Cassiano. Associação entre a composição muscular da musculatura da coxa com mortalidade em pacientes recém-diagnosticados com câncer colorretal. Orientadora: Dra. Ana Paula Trussardi Fayh. 2024. 33f. Dissertação (Mestrado em Ciências da Saúde) - Centro de Ciências da Saúde, Universidade Federal do Rio Grande do Norte, Natal, 2024.https://repositorio.ufrn.br/handle/123456789/60505Introduction: Colorectal cancer (CRC) is one of the main causes of morbidity and mortality worldwide. Patients with RCC often have low skeletal muscle mass associated with a worse prognosis. Objectives: To verify associations between thigh muscle parameters, assessed by computed tomography (CT) images, and adverse outcomes in patients with RCC. Methods: This multicenter cohort study with retrospective data collection, including adults (> 18 years). Thigh muscle parameters were analyzed in patients newly diagnosed with RCC, using CT as the evaluation method. CT images were analyzed to assess skeletal muscle (SM in cm²), skeletal muscle index (SMI in cm²/m²), and skeletal muscle density (SMD in HU). Muscle abnormalities (low SM, low SMI, and low SMD) were defined as values below the median by gender. Results: A total of 257 patients were included in the final analysis. The mean age of the patients was 62.6 ± 12.1 years and 50.2% (n = 129) were female. Kaplan-Meyer curves and hazard ratios (HR) for low MWS, MFS, and DFS were evaluated for overall mortality, stratified by sex. In men, low SMI of the thigh was associated with a 50% lower probability of survival (log-rank p = 0.02). In addition, low SMI (cm2/m2) was independently associated with higher mortality rates (adjusted HR 2.08, 95% CI 1.03 to 4.18). The outcome relating to clinical TNM stages, low MDS was independently associated with mortality in stages I-III (adjusted HR 2.78, 95% CI 1.26 to 6.15). Conclusion: Analyses of thigh muscle parameters using CT images showed an association between SMI parameters and MDS with overall mortality in patients newly diagnosed with RCC.Acesso AbertoCâncerMassa muscularRadiodensidade muscular esqueléticaÍndice muscular esqueléticoMortalidadeComposição corporalmasterThesisCNPQ::CIENCIAS DA SAUDE