Balen, Sheila AndreoliEvangelista, Carolina Karla de Souza2019-12-112021-09-202019-12-112021-09-202019-11-29EVANGELISTA, Carolina Karla de Souza. Caracterização das respostas neurais subcorticais da via auditiva em bebês expostos à sífilis. 2019. 40 f. Trabalho de Conclusão de Curso (Graduação em Fonoaudiologia) - Departamento de Fonoaudiologia, Universidade Federal do Rio Grande do Norte, Natal, 2019.https://repositorio.ufrn.br/handle/123456789/36036Objectives: Syphilis is a bacterial disease that occurs with sexual contact transmission of the bacterium Treponema Pallidum. When a woman is pregnant and not treated or inadequately treated, transmission of syphilis to the baby may occur. Among the symptoms, the literature describes the injury of the VIII cranial nerve and thus the sensorineural hearing loss, as well as other cognitive and neurological manifestations. Currently, the literature lacks studies demonstrating the repercussion of syphilis on the central, subcortical and mesencephalic auditory pathways. The frequency-following response (FFR) is a procedure that can be used as a noninvasive electrophysiological measure that provides information about the auditory processing quality of sounds in the auditory pathway and speech acoustic configurations in subcortical areas. Thus, the objective of this study was to characterize the neural responses of babies exposed to syphilis. Design: The sample consisted of 49 subjects, with a mean age of 38.3 ± 15.8 days of life. They were classified into three groups: G1 consisted of 11 babies with mothers who had prenatal syphilis treatment; G2 composed of 20 babies of mothers who treated perinatal syphilis; G3 of 18 babies whose mothers did not have syphilis. All subjects attested auditory pathway integrity at 80dBnNA and presence of V wave at 30dBnNA in click ABR. The frequency-following response (FFR) procedure was performed at the intensity of 80dBnNA in the right ear, using the consonant-vowel /da/ stimulus, lasting 170 ms. Four promediations of 1000 sweeps were performed, totaling 4000. The following parameters were analyzed: cross-correlation between stimulus and response, pitch error and pitch strength, signal-to-noise ratio, neural lag, fundamental frequency spectral amplitude, its harmonics on a fixed time window and points below noise floor. The Shapiro-Wilk test was used to test data normality and the non-parametric Kruskall-Wallis test for comparison between groups, adopting a significance level of 5%. Results: There were no statistically significant evidences for the parameters analyzed either in the time domain nor in the frequency domain, between the groups of prenatal, perinatal and control infants. Conclusions: This study shows that when treated, exposure to syphilis does not influence the processing of sounds and their temporal and spectral characteristics.Attribution-NonCommercial-NoDerivs 3.0 Brazilhttp://creativecommons.org/licenses/by-nc-nd/3.0/br/Sífilis CongênitaAudiçãoPotenciais Evocados AuditivosbachelorThesis