Silveira, Éricka Janine Dantas daAlves, Kézia Raphaela de Lucena2016-11-302021-09-272016-11-302021-09-272016-06-08ALVES, Kézia Raphaela de Lucena. Estudo clínico-patológico e de acompanhamento em uma série de casos de leucoplasias orais. 2015. Monografia (Graduação) - Departamento de Odontologia, Universidade Federal do Rio Grande do Norte, Natal, 2015.https://repositorio.ufrn.br/handle/123456789/39323This research aimed to conduct a clinicopathologic study and monitoring in a case series of oral leukoplakia (OL). The sample consisted of 54 cases of OLs diagnosed in a period of 10 years, of which demographic and clinical data from medical records were collected. Analysis of histological grading of cases submitted to biopsy and clinical follow-up was performed. Statistical tests were performed adopting a significance level of 5% (p ≤ 0.05). Of the total sample, the majority were female (63%) and the mean age of patients was 58.93 years. Dark brown or black type of skin (61,1%) was predominant and the vast majority reported being smokers or former smokers (81.5%). Half of the patients had multiple lesions in more than one location (50%). The oral mucosa was the more committed site (30.3%) with predominance of homogeneous leukoplakia (70.8%). Biopsies were performed in 35 cases considering the histological grading the binary system the majority of cases were diagnosed as lesion with low risk of malignant transformation (34.4%). Only 18 patients returned for clinical follow-up evaluation. The follow-up period ranged from 3 to 96 months and 11 patients (61.1%) showed no recurrence. There were no statistically significant differences between the variables and histopathologic gradations of malignancy. According to our results, the clinical parameters of LOs are not associated with morphological degree of risk of malignant transformation of the lesions.openAccessLeucoplasia BucalNeoplasias BucaisDiagnóstico bucalbachelorThesis