Morais, Ana Heloneida de AraújoNascimento, Sara Sayonara da Cruz2021-06-152021-06-152021-03-30NASCIMENTO, Sara Sayonara da Cruz. Mecanismos de ação de agentes anti-inflamatórios no tecido adiposo. 2021. 63f. Dissertação (Mestrado em Nutrição) - Centro de Ciências da Saúde, Universidade Federal do Rio Grande do Norte, Natal, 2021.https://repositorio.ufrn.br/handle/123456789/32708Obesity is characterized by an expansion of the mass of adipose tissue and changes in its distribution in the body, being associated with an automatic increase in circulating inflammatory mediators. Anti-inflammatory agents are presented as an alternative treatment for obesity, being tested in animal and human models. This study aimed to gather studies published in the specialized literature to answer the following question: "What are the mechanisms of action of antiinflammatory agents in adipose tissue?". For this, through a secondary study, bulletin, a protocol for obtaining a systematic review was prepared and registered in the International Prospective Registry of Systematic Reviews (PROSPERO). Thus, preferred report items for systematic review and meta-analysis protocols (PRISMA-P) were used to outline the protocol and PRISMA for a systematic review. The articles were selected according to the eligibility criteria according to the PICOS (population, processing, control, results and type of study). The databases used for research were PubMed, ScienceDirect, Scopus, Web of Science, BVS and EMBASE. Experimental studies carried out in rats and mice with a control group that describe treatment with anti-inflammatories (drugs, nutraceuticals, bioactive compounds, among others) were included at any frequency, time and dose. The articles were selected, and the data were extracted by three independent reviewers. The evaluation of the methodological quality of each survey was carried out using the SYRCLE tool. The review was registered with PROSPERO under number: CRD42020182897 and the protocol published in a scientific journal. For systematic review, 1263 articles were selected, with 27 qualified at the end of the search for a review. Among the classes of anti-inflammatory agents, 6 drugs, 17 natural compounds and four synthetic compounds were identified. In view of the studies, it can be inferred that a large part of the bioactive compounds, drugs and synthetic compounds act in metabolic pathways that culminate, mainly, in the reduction of the expression of inflammatory cytokines, which favors a reduction in the infiltration of macrophages in white and adipose tissue. cause polarization process of macrophages of type M1 to M2. It can be noted that the inflammatory pathways overlap to explain the mechanism of action of drugs, natural and synthetic compounds. In view of the heterogeneity of the data, there was no grouping and it was not possible to carry out the meta-analysis. Thus, the systematic review clarifies and systematizes the compound components and drugs in adipose tissue, being of great ex. And generating information for future research on these pathways, the treatment is the most effective treatment of inflammation in obesity.Acesso AbertoInflamaçãoTecido adiposoObesidadeRevisão sistemáticaMecanismos de ação de agentes anti-inflamatórios no tecido adiposomasterThesis