Nascimento, Manuela Sales LimaBezerra, Wallace Pitanga2023-02-152023-02-152022-12-12BEZERRA, Wallace Pitanga. Crianças com microcefalia por síndrome congênita do vírus Zika apresentam inflamação sistêmica persistente durante a infância. 2022. 89 f. Trabalho de Conclusão de Curso (Graduação em Biomedicina) – Centro de Biociências, Universidade Federal do Rio Grande do Norte, Natal, 2022.https://repositorio.ufrn.br/handle/123456789/51300The Zika virus (ZIKV) epidemic between the years of 2015 and 2016 elevated considerably the number of children born with microcephaly during that period, children who later would be characterized as having the Congenital zika virus syndrome (CZVS). Previous findings show an immunological imbalance in neonates with CZVS, and our group has already demonstrated immunological alterations in this population. In this present paper, we aimed to further investigate inflammatory markers and its consequences in children with CZVS. We recruited microcephalic children with clinical and/or serological diagnosis of CZVS and healthy children without any neuromotor condition to compose the control group. We did quantitative polymerase chain reaction (qPCR) and cytometric bead array (CBA) to assess these immunological markers in whole blood or serum. The children’s legal guardians also answered a allergic profile questionnaire. We were able to note that children with CZVS had elevated expression of interferon (IFN)-γ and IL-13, both antagonic cytokines, even in the absence of symptomatic infections or asymptomatic parasitic infections; furthermore, we observed low levels of CCL2 and almost absence of CXCL8 in microcephalic children when compared to the control group. We also noted a high prevalence of allergies through the allergic profile questionnaire and, with that in mind, we dosed seric levels of IgE antibodies, but we did not see any difference between the microcephalic and the control groups. The data here described helps to elucidate the full extent of the ZIKV congenital infection, and the investigation of the immunological characteristics of this condition can help better adequate therapeutic and vaccination schemes to the microcephalic children specific needs.Attribution-NonCommercial-NoDerivs 3.0 Brazilhttp://creativecommons.org/licenses/by-nc-nd/3.0/br/Síndrome congênita do vírus ZikaInflamaçãoAlergiaCongenital Zika virus infectionInflammationAllergybachelorThesisCNPQ::CIENCIAS BIOLOGICAS::IMUNOLOGIA