Pereira, Kércia Regina Santos GomesAçucena, Maria Kadja Meneses TorresVillarim Neto, ArthurRêgo, Amália Cínthia MenesesBernardo Filho, MárioAzevedo, Ítalo MedeirosAraújo Filho, IramiMedeiros, Aldo Cunha2013-10-212013-10-212008PEREIRA, Kércia Regina Santos Gomes ; AÇUCENA, Maria Kadja Meneses Torres ; VILLARIM NETO, Arthur ; RÊGO, Amália Cínthia Meneses; BERNARDO FILHO, Mário; AZEVEDO, Ítalo Medeiros; ARAÚJO FILHO, Irami; MEDEIROS, Aldo Cunha. Biodistribution of the radiopharmaceutical technetium-99m-sodium phytate in rats after splenectomy. Brazilian Archives of Biology and Technology , v. 51, p. 203-207, 2008. Disponível em: <http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1516-89132008000700033> Acesso em: 09 out. 2013.1516-8913https://repositorio.ufrn.br/jspui/handle/1/6625Drugs and surgery can interfere with the biodistribution of radiopharmaceuticals and data about the effect of splenectomy on the metabolism of phytate-Tc-99m are scarce. This study aimed at evaluating the interference of splenectomy on phytate-Tc-99m biodistribution and liver function in rats. The SP group rats (n=6) underwent splenectomy. In group C (control) the animals were not operated on. After 15 days, all rats were injected with 0.1mL of Tc-99m-phytate via orbital plexus (0.66MBq). After 30 minutes, liver samples were harvested, weighed and the percentage of radioactivity per gram (%ATI-g) was determined by a Wizard Perkin-Elme gama counter. The ATI%-g in splenectomized rats (0.99±0.02) was significantly higher than in controls (0.4±0.02), (p=0.034). ALT, AST and HDL were significantly lower in SP rats (p= 0.001) and leukocytosis was observed in SP rats. In conclusion, splenectomy in rats changed the hepatic biodistribution of Tc-99m-phytate and liver enzimatic activityengAcesso AbertoSplenectomySodium phytateBiodistributionLiverarticle