Araújo, Draulio Barros dePessoa, Jéssica de Andrade2017-11-172017-11-172017-07-27PESSOA, Jéssica de Andrade. Marcadores espectrais de eletroencefalografia observados durante os efeitos agudos da ayahuasca e sua relação com a experiência psicodélica. 2017. 81f. Dissertação (Mestrado em Neurociências) - Universidade Federal do Rio Grande do Norte, Universidade Federal do Rio Grande do Norte, Natal, 2017.https://repositorio.ufrn.br/jspui/handle/123456789/24291Ayahuasca is a brew with psychedelic properties largely used by indigenous populations from the Amazon basin. It contains the psychedelic tryptamine N,N-dimethyltriptamine (DMT), and monoamine oxidase inhibitors (iMAO), such as harmine and harmaline. Ayahuasca is consid-ered to be a serotonergic psychedelic, capable of inducing an altered state of consciousness with similarities to an oneiric experience, with intense alterations in perception, though, humor, emo-tion, and mystical-type experiences. The neural correlates of its acute effects have been inves-tigated by different neuroimaging techniques, including electroencephalography (EEG). In this study, we explored EEG spectral changes in 48 healthy volunteers using a randomized double-blind placebo-controlled trial. Half of the volunteers received ayahuasca, half received placebo. We used an EEG system to monitor all volunteers throughout the dosing session, which lasted approximately 4-hours. Aiming to improve data quality, the volunteers were asked to perform two controlled tasks at three specific moments: before intake, 2h and 4h after intake. For the first task, they alternated moments of eyes open (20 seconds) with eyes closed (40 seconds) for 5 minutes, avoiding falling asleep. During the second task they should keep their eyes closed for another 5 minutes, again avoiding falling asleep. Spectral analysis at 2h after intake shows reduced alpha power, and increased theta and beta in the ayahuasca group with respect to the placebo, mainly in occipital and right temporoparietal regions. Correlation analysis revealed correspondences between the alpha power (2h) and individual scores on two scales used to measure psychedelic effects – the Hallucinogen Rating Scale (HRS) and the Mystical Experi-ence Questionnaire (MEQ). Additionally, we also present EEG traces with electrophysiological events that might be of importance for the representation of the psychedelic experience. Over-all, our results suggest that the inhibition of alpha oscillations, increased theta and beta in right posterior brain regions play an important role on the psychedelic experience, maybe sharing mechanisms present during the oneiric experience.Acesso AbertoAyahuascaEletroencefalografiaAnálise espectralAlfaSonhoHRSMEQmasterThesisCNPQ::OUTROS::CIENCIAS: NEUROCIÊNCIAS