Pedrosa, Matheus de Freitas FernandesPinheiro, Ilanna Tainá Medeiros Gurgel2025-11-032025-11-032016-03-01PINHEIRO, Ilanna Tainá Medeiros Gurgel. Parâmetros inflamatórios e fisiopatológicos do envenenamento induzido pelo escorpião Tityus stigmurus em camundongos. Orientador: Dr. Matheus de Freitas Fernandes Pedrosa. 2016. 124f. Dissertação (Mestrado em Ciências Farmacêuticas) - Centro de Ciências da Saúde, Universidade Federal do Rio Grande do Norte, Natal, 2016.https://repositorio.ufrn.br/handle/123456789/66003Scorpion bites are responsible for significant morbidity and pediatric mortality in many parts of the world and represents a public health problem in Brazil. Tityus stigmurus is a scorpion specie of medical importance that occur in the Brazilian Northeast. In this context, this work proposed to analized the inflammatory and pathophysiological parameters after Tityus stigmurus scorpion envenoming in vivo by intraperitoneal injection of 375 µg/kg of venom in BALB/c mice to evaluate its local and systemic effects. For this purpose, the total and differential leukocyte number, myeloperoxidase activity, nitrite levels and total protein were quantified in peritoneal exsudate, as well as, serum biochemical parameters and cytokine (TNF-α and IL-10) levels were analyzed. Alterations in relative organs weight of the experimental animals were also assessed. The results showed that the venom was not able to induce the migration of cells into the peritoneum of experimental animals. However, significant biochemical abnormalities were observed as the increase in CK, CK-MB, AST, ALT, creatinine, amylase, and uric acid. Moreover, it was observed lesions in organs such as heart, liver, kidney and pancreas. It was also demonstrated edema response that was characterized by rapid onset, lasting up to 1 hour. This is the first time that partial characterization of the envenoming induced by T. stigmurus in mice was carried out.pt-BRAcesso AbertoTityus stigmurusEnvenenamentoInflamaçãoEdema de patamasterThesisCIENCIAS DA SAUDE::FARMACIA