Andrade Neto, Valter Ferreira deAndrade, Joelma Maria de Araújo2018-12-102018-12-102018-08-31ANDRADE, Joelma Maria de Araújo. Estudo de polimorfismos nos genes IL17A e IL17RA e da produção de IL-17A, IL-33 e CCL2 em gestantes infectadas pelo Toxoplasma gondii do Estado do Rio Grande do Norte, Brasil. 2018. 89f. Dissertação (Mestrado em Ciências Biológicas) - Centro de Biociências, Universidade Federal do Rio Grande do Norte, Natal, 2018.https://repositorio.ufrn.br/jspui/handle/123456789/26300Toxoplasma gondii (T. gondii) is a parasitic infectious parasitic disease that is an obligate intracellular parasite capable of determining a delicate balance between parasitism and the immune response of the host, which is modified due to environmental and genetic factors. Due to this, we aimed to investigate the allelic and genotype frequencies of specific SNPs in the IL17A and IL17RA genes, as well as the production of IL-17A, IL-33, and CCL2 in pregnant women infected with T. gondii from the State of Rio Grande do Norte, Brazil. Through PCR-RFLP techniques, two SNPs implicated in Th17 immune response, IL17A rs2275913 (G> A) and IL17RA rs4819554 (A> G) modulation were evaluated in pregnant women, infected or not by T. gondii and treated in Maternity School Januário Cicco, Natal / RN. These women were also evaluated for the production of cytokines involved in the modulation of the immune response, CCL2, IL-33, and IL-17A, by the direct ELISA method. The results showed that the G-allele of the SNP rs2275913 (IL17A) appeared to be protective in this population, while the rs4819554 (IL17RA) SNP G allele was associated with a greater susceptibility to T. gondii infection [P value = 0.025; OR = 2.815 (1.118-7.089); CI = 95%]. Regarding cytokines, none of them had any influence on the analyzed parameters (abortion and hypertension). In view of these results, this unpublished study brings important immunogenic evidence in humans that support the existence of a contribution of the host genotype to the immunomodulation result of T. gondii; this still opens perspectives for other future approaches of the parasite-host relationship.Acesso AbertoToxoplasma gondiiGestantesPolimorfismoCitocinasSintomatologiamasterThesisCNPQ::CIENCIAS BIOLOGICAS