Oliveira, Ana Katherine da Silveira Gonçalves deQueiroz Filho, José2018-09-192018-09-192018-02-21QUEIROZ FILHO, José. Avaliação do desempenho da revisão rápida de 100% como ferramenta efetiva para controle interno de qualidade em laboratórios de citopatologia. 2018. 79f. Tese (Doutorado em Ciências da Saúde) - Centro de Ciências da Saúde, Universidade Federal do Rio Grande do Norte, Natal, 2018.https://repositorio.ufrn.br/jspui/handle/123456789/25884Cervical cancer is the third most common cancer and the fourth leading cause of death in women worldwide. The incidence has declined considerably in developed countries through organized screening programs, which link the Pap smear to molecular biology examinations, thus achieving good diagnostic accuracy. The effectiveness of these programs can be proven by the reduction in the mortality rate caused by cervical cancer. In the least developed countries, molecular biology is not available, which, coupled with few resources and unstructured laboratories, has contributed to the decrease in quality of cervical cancer screening. The aim of this study was to evaluate the 100% rapid review (100%-RR) as an effective tool for internal quality control (IQC) in gynecological cytopathology services in the state of Rio Grande do Norte- Brazil. A total of 8,677 swabs were analyzed; the negative results were submitted to 100%-RR. Divergent cases were discussed in a consensus meeting to reach a conclusion on the final diagnosis. The data were entered into SAS statistical software, and the agreement of the 100%-RR results with the final diagnosis was tested with the weighted kappa statistic. Of the 8,155 smears characterized as negative, 255 (3.13%) were abnormal smears, and 552 (6.77%) unsatisfactory smears were deemed negative. Regarding the results on the 8,155 smears subjected to 100%-RR when compared with the final diagnosis, there was agreement in 7,063 (86.60%) of them, and there were 1,092 (13.40%) discordant results (65.6%, unsatisfactory; 5.47%, atypical squamous cells of undetermined significance [ASCUS]). The κ index had an agreement of 0.867, with κ = 0.734 (p < 0.0001). Compared with the final diagnosis, the sensitivity of 100%-RR was 99.91% and its specificity was 99.4% for severe abnormalities. The sensitivity for high-grade squamous intraepithelial lesions was 88.2%, with a specificity of 100.00%. For abnormalities considered borderline, such as ASC-US, the sensitivity was 94.50% and the specificity was 99.5%. The 100%-RR was considered efficient when used as an IQC method.Acesso AbertoControle de qualidadeSensibilidadeDiagnósticoPrecisãoCitologiadoctoralThesisCNPQ::CIENCIAS DA SAUDE