Pereira, Hallissa Simplicio GomesMoreno, Mariana Cabral2019-11-282019-11-282019-07-04MORENO, Mariana Cabral. Efeito da cafeína na movimentação ortodôntica e no comportamento de ratos: estudo experimental in vivo. 2019. 57f. Dissertação (Mestrado em Ciências Odontológicas) - Centro de Ciências da Saúde, Universidade Federal do Rio Grande do Norte, Natal, 2019.https://repositorio.ufrn.br/jspui/handle/123456789/28071OBJECTIVE: To verify the effect of caffeine on orthodontic movement (MO) and behavior of rats. METHODS: In this randomized in vivo experimental study, 12 healthy male Wistar rats (Rattus norvegicus albinus), 7-12 weeks, 200-300g were used. These animals were submitted to OM (closed NiTi spring (50cN) between 1st molar and upper incisors / left side) and daily administration of caffeine (3g / L) and water by gavage for 21 consecutive days. The sample was divided into two groups: a) control (n = 7): submitted to OM and water; b) experimental (n = 5): submitted to OM and caffeine. The amount of OM was verified by a dry point compass and millimeter ruler at the beginning and end times. The open field test was used in the four-stage behavioral assessment: baseline (T0), after spring placement (T1), after 2nd gavage (T2), after 21 days (T3). Then, Mann-Whitney statistical tests (amount of OM) and Friedman test / Wilcoxon test (behavior) were performed at a significance level of 5%. RESULTS: Caffeine did not interfere with OM (p> 0.05). Regarding the open field test, statistically significant values (p> 0.05) were identified in several parameters. CONCLUSION: Caffeine did not influence the amount of macroscopic orthodontic movement, despite exhibiting anxiogenic effect on rat behavior.Acesso AbertoOrtodontiaTécnicas de movimentação dentáriaRatosmasterThesisCNPQ::CIENCIAS DA SAUDE::ODONTOLOGIA