Gavioli, Elaine CristinaCarvalho, Marlon Barbosa Dantas de2021-03-052021-03-052020-10-22CARVALHO, Marlon Barbosa Dantas de. Participação do eixo hipotálamo-pituitária-adrenal na modulação do comportamento tipo depressivo induzido pela ativação de receptor de nociceptina/orfanina FQ. 2020. 58f. Dissertação (Mestrado em Psicobiologia) - Centro de Biociências, Universidade Federal do Rio Grande do Norte, Natal, 2020.https://repositorio.ufrn.br/handle/123456789/31710Several studies have linked the N/OFQ-NOP receptor system with depressed mood disorder. Despite the notorious antidepressant effects of NOP antagonists in different behavioral tests and animal models of depression, little is known about the behavioral actions of NOP agonists under stress conditions. The present study aimed to investigate the participation of the hypothalamicpituitary-adrenal (HPA) axis in the NOP agonist-induced depressive-like behaviors in mice treated prior to the first exposure to the forced swim test. The effects of the treatment with the tricyclic antidepressant nortriptyline, a NOP agonist (Ro 65-6570) and a NOP antagonist (SB-612111) before exposure to forced swimming stress was investigated. In addition, in order to evaluate the participation of the HPA axis in the effects of the NOP agonist (Ro 65-6570) in the forced swim stress, mice were pretreated with CRF1 receptor antagonist (NBI 30755), glucocorticoid receptor antagonist (mifepristone) and glucocorticoids synthesis inhibitor (aminoglutethimide). Firstly, the administration of the nortriptyline prior to exposure to the forced swim did not affect mouse behavior when compared to the control group. However, an increase in the immobility time was observed in mice treated with the NOP agonist, Ro 65-6570, while a decrease in the immobility time was detected in those animals treated with the NOP antagonist, SB-612111, being both drugs administered before stress, when compared to the control group. Finally, it was observed that the effects of Ro 65-6570 in the immobility time were blocked when mice were pretreated with mifepristone, NBI 30755 or aminoglutethimide. However, there were no effects of the HPA axis blocking agents per se on the behavior of mice in the forced swim stress. In conclusion, the activation of NOP receptor promotes depressive-like effects, while the blockade produces opposite effects. In addition, the depressive-like effects of NOP agonists appear to be mediated by the HPA axis.Acesso AbertoDepressãoNociceptina/orfanina FQEixo HPA camundongoNatação forçadamasterThesis