Lima, Kássio Michell Gomes deAndrade, Eduardo Wagner Vasconcelos de2017-11-172021-09-272017-11-172021-09-272017-11-03ANDRADE, Eduardo Wagner Vasconcelos de. Transferência de cartas de controle multivariada empregando espectrômetros NIR para determinação simultânea de rifampicina e isoniazida numa formulação farmacêutica. 2017. 77f. Trabalho de Conclusão de Curso (Graduação em Engenharia Química), Departamento de Engenharia Química, Universidade Federal do Rio Grande do Norte, Natal, 2017.https://repositorio.ufrn.br/handle/123456789/38705This study reports a new multivariate control chart transfer approach between two near infrared (NIR) spectrometers for simultaneous determination of rifampicin and isoniazid in pharmaceutical formulation using direct standardization (DS). The control charts are based on the calculation of net analyte signal (NAS) models and the transfer samples are selected by the Kennard-Stone (KS) algorithm. Three control (NAS, interference and residual) charts transfer on both the master and slave instruments were measured. As a result, a classification model for rifampicin and isoniazid developed on a primary instrument has been successfully transferred to a secondary instrument. The spectral differences after the standardization procedure reduced considerably and errors values found in the charts for both analytes were comparable with the errors obtained for the original chart models. The proposed approach appears to be a valid alternative to the commonly used transfer of multivariate calibration models.openAccessTransferência de cartas de controle multivariadasSinal analítico líquidoIsoniazidaRifampicinaPadronização diretaNIRbachelorThesisEngenharias.