Torres, Gilson de VasconcelosToscano, Gislani Acásia da Silva2021-09-082021-09-082021-06-28TOSCANO, Gislani Acásia da Silva. Suplementação de vitamina C e D e a gravidade de COVID-19. 2021. 35f. Dissertação (Mestrado em Ciências da Saúde) - Centro de Ciências da Saúde, Universidade Federal do Rio Grande do Norte, Natal, 2021.https://repositorio.ufrn.br/handle/123456789/33297Context: The Covid-19 pandemic quickly spread to other countries, causing numerous deaths. Diet and nutrition invariably influence the competence of the immune system and determine the risk and severity of infections. Methods: In this context, this protocol describes a systematic review aiming to analyze whether vitamin C and D supplementation can reduce the severity of Covid-19. This protocol was developed based on the PRISMA-P recommendations. To carry out the systematic review, we will perform searches in the PubMed, Web of Science, Scopus, Cochrane and ScienceDirect databases in search of case-control studies that analyze the supplementation and evolution of patients with COVID-19. There will be no limitations related to language or time of publication. Searches will be performed by two independent researchers who will select articles and then duplicate studies will be removed, while suitable ones will be selected using the Rayyan QCRI application. To assess the risk of bias, we will use the instrument proposed by the National Heart, Lung and Blood Institute. In addition, we will perform meta-analyses and subgroup analyzes according to the conditions of the included data. Results: This review will assess the association between vitamin C and D supplementation and reduced severity of COVID-19. Conclusion: The results of this systematic review will summarize the latest evidence for the association between vitamin C and D supplementation and COVID-19 through a systematic review and meta-analysis.Acesso AbertoCovid-19Síndrome Respiratória Aguda Grave do CoronavírusVitamina CVitamina DmasterThesis