Reis, Bruna ZavarizeAlbuquerque, Ana Beatriz Bessa deFernandes, Alan Lins2024-03-012024-03-012021-10ALBUQUERQUE, Ana Beatriz Bessa de; FERNANDES, Alan Lins; REIS, Bruna Zavarize. Vitamina D em pacientes com COVID-19: atuais perspectivas. Research, Society and Development, [S.l.], v. 10, n. 13, p. 1-11, 9 out. 2021. DOI: 10.33448/rsd-v10i13.21167. Disponível em: https://rsdjournal.org/index.php/rsd/article/view/21167. Acesso em: 19 fev. 2024.https://repositorio.ufrn.br/handle/123456789/57734The search for therapeutic resources that add to the vaccine and are able to prevent and/or treat COVID-19 suggests vitamin D. Vitamin D is known to play several extra-skeletal roles in the body, particularly in the immune system. This review aims to address the current attributions and perspectives for the use of vitamin D in patients with COVID19. The search was performed using the Medline (PubMed) database, between May and July 2021, regarding the physiological and immunological roles of vitamin D in respiratory infections, as well as its mechanisms of action, concerning COVID- 19. The results suggest a possible association between serum 25(OH)D concentrations and the clinical setting of COVID-19 (mortality, systemic inflammation, illness severity, mechanical ventilation requirement or admission to the ICU), although the studies found differ in the design, sample size and outcomes, mitigating an accurate between-trial comparison. Therefore, further studies with a well-defined design evaluating the role of vitamin D in the prevention and/or treatment of COVID-19 is still necessaryAttribution 3.0 Brazilhttp://creativecommons.org/licenses/by/3.0/br/25OHDColecalciferolErgocalciferolSARS-CoV-2CoronavírusCOVID-19CholecalciferolCoronavirusesarticlehttp://dx.doi.org/10.33448/rsd-v10i13.21167