Brandão, Deysiane OliveiraSilva, Valdemar Menezes da2025-01-242025-01-242024-12-19SILVA, Valdemar Menezes da. Alterações hematológicas na doença de Chagas: uma revisão integrativa. Orientadora: Deysiane Oliveira Brandão. 45 f. 2024. Monografia (Graduação em Biomedicina) – Universidade Federal do Rio Grande do Norte, Natal, 2024.https://repositorio.ufrn.br/handle/123456789/61932Chagas disease is a neglected disease that presents high morbidity and mortality rates, constituting a major challenge to public health. The disease is found in 21 countries in Latin America, with estimates that between 6 and 8 million people are infected. Cardiac and digestive manifestations are quite common; however, the disease also presents significant hematological changes. Therefore, this study aims to review the main hematological changes associated with Trypanosoma cruzi infection and evaluate their relevance in the prognosis of Chagas disease. To this end, an integrative literature review was carried out by consulting the Lilacs, PubMed, and Scielo databases. The descriptors used were: (Chagas Disease OR Trypanosoma cruzi) AND (abnormalities OR Leukocytes OR Leukopenia OR Anemia OR Blood Cell Count OR Blood Coagulation OR Thrombocytopenia). The inclusion criteria covered scientific articles that addressed hematological changes in Chagas disease in humans from the last 10 years and were available in English, Spanish, and Portuguese. The exclusion criteria were applied to studies of Chagas disease in non-human animals, research that did not address hematological changes, and studies with more than 10 years of publication. After applying the inclusion and exclusion criteria, 11 articles were eligible to be included in the review. In the results and discussions, the most observed changes included anemia, increased levels of prothrombin fragment (F1+2) and endogenous thrombin potential (ETP), thrombocytopenia, leukocytosis, altered platelet activation, and increased pro-inflammatory cytokines. In conclusion, hematological changes, such as anemia, leukocytosis, and thrombocytopenia, appear to be linked to Trypanosoma cruzi infection and may serve as prognostic indicators for the disease. Changes in platelet activation and elevated levels of prothrombin fragment (F1 + 2) and endogenous thrombin potential (ETP) were the events most related to thromboembolic risks, indicating a poor prognosis. Pro-inflammatory cytokines (IL-6, TNF-α) were also remembered as complicating the disease.Attribution 3.0 Brazilhttp://creativecommons.org/licenses/by/3.0/br/Trypanosoma cruziTrypanosoma cruziAnemiaAnemiaTrombocitopeniaThrombocytopeniaCoagulação sanguíneaBlood coagulationContagem de células sanguíneasBlood cell countbachelorThesisCNPQ::CIENCIAS BIOLOGICAS::PARASITOLOGIA