Souza, Gustavo Antônio deLemos, Juliana de Oliveira2022-09-022022-09-022022-07-21LEMOS, Juliana de Oliveira. Metanálise de dados proteicos para determinar proteínas comumente presentes em diferentes modelos experimentais relacionados ao transtorno de espectro autista. 2022. 52 f. Monografia (Graduação em Biomedicina) – Universidade Federal do Rio Grande do Norte, Natal, 2022.https://repositorio.ufrn.br/handle/123456789/49247The Autism Spectrum Disorder (ASD) encompasses a group of conditions: childhood autism, Rett Syndrome, Asperger Syndrome, childhood disintegrative disorder, hyperkinesia disorder, among others, characterized by deficits in socio-emotional reciprocity, non – verbal communicative behaviors, deficits in developing, maintaining and understanding relationships and presents restrictive patterns of behavior, interests or activities. Over the years, there has been an increase in the number of individuals diagnosed with ASD, however, in many cases, late, since the diagnosis is still only based on the patient's clinical symptoms and requires specialized professionals to do so. Several studies have tried to clarify the pathophysiological basis of autism, looking for possible biomarkers that can help both in the diagnosis and treatment of this condition. The aim of this study was to search for protein profiles that may be involved in biological processes participating in neural pathways related to the disorder, through meta-analysis of data from experimental models of autistic disorder, using bioinformatics approaches to obtain and analyze data. The results showed that some of the molecules, such as: Psd-95, Gria, Shank3, Synapsin, Calmodulin, Kinases, Snap25, among others described, are responsible for a variety of processes associated with synaptic transmission (assembly, activation, of receptors of glutamate, transport through the cytoskeleton of microtubules, in the regulation and release of neurotransmitters, as well as the entire signaling structure, phosphorylation and postsynaptic density) showed a functional enrichment of their pathways. All these processes form the basis for the formation of synaptic plasticity, related to learning, memory, behavior and sensory perceptions that may be involved in the pathophysiology of the disorder, since the symptoms presented by patients are directly linked to the aforementioned processes. However, it is still necessary to continue the analysis for validation and verification of the results obtained, in addition to new analyzes to investigate other possible proteomes and biological processes related to Autism Spectrum Disorder.AutismoProteomaFisiopatologiaTransmissão sinápticaNeuroplasticidadeAutismProteomePathophysiologySynaptic transmissionNeuroplasticitybachelorThesis