Pedrosa, Matheus de Freitas FernandesSantos, Jacinthia Beatriz Xavier dos2019-05-072019-05-072018-12-19SANTOS, Jacinthia Beatriz Xavier dos. Avaliação da atividade anti-inflamatória de géis a base de extratos vegetais de plantas do nordeste brasileiro: Jatropha gossypiifolia e Ipomoea pes-caprae. 2018. 103f. Dissertação (Mestrado em Ciências Farmacêuticas) - Centro de Ciências da Saúde, Universidade Federal do Rio Grande do Norte, Natal, 2018.https://repositorio.ufrn.br/jspui/handle/123456789/26992The inflammatory process is a physiological event, whose events generated in this process are caused by the release of inflammatory mediators, aiming to restore homeostasis. Anti-inflammatory drugs are used for the treatment of inflammations, however, prolonged therapy leads to the appearance of adverse reactions that may be harmful to the patient, and the search for new, safer and more effective alternatives becomes relevant. In this context, medicinal plants, such as the plant species Jatropha gossypiifolia (Jg) and Ipomoea pes-caprae (Ipc) can be highlighted as strong candidates, since in traditional medicine they are popularly used for a wide range of curative purposes, including inflammatory conditions. In this sense, in the present study the obtain of gels containing the vegetal extracts of these species and the evaluation of their topical antiinflammatory activity were carried out, using the models of ear edema induced by single application of crton oil and paw edema induced by carrageenan (acute inflammation) and ear edema induced by multiple application of chrotonic oil (chronic inflammation). The gels presented adequate physico-chemical characteristics and were stable during 30 days of observation, showing no change in color, odor or appearance. The gels had pH similar to the cutaneous pH, thus minimizing the appearance of irritation or cutaneous alteration, results that corroborated with the in vivo skin irritation test, where the gels showed no clinical signs of toxicity between the 14 days of observation, indicating product safety developed for topical use. Jg gels demonstrated significant acute antiinflammatory activity in ear edema, and this activity was significantly increased when equivalent amounts of the extract were applied incorporated into the developed gels, and also reduced the levels of edema, nitrite and MPO enzyme in the gels. ears of mice, with intensity similar to dexamethasone (anti-inflammatory pattern). The Ipc extract showed no activity in the acute ear edema model, even after gel incorporation, however, it significantly inhibited paw edema throughout the duration of the dexamethasone-like experiment. Gels of 1.0% and Ipc 5% also showed a significant anti-inflammatory effect in the chronic inflammation test, reducing edema (also observed in the histopathological analysis) and oxidative (lipid peroxidation and reduced glutathione depletion) dexamethasone. Thus, this study demonstrated the anti-inflammatory potential of the gels with the extracts of the species J. gossypiifolia and I. pes-caprae, and can serve as starting point for the development of herbal products for the treatment of inflammatory processes.Acesso AbertoFitoterápicosInflamaçãoFormulação tópicaJatropha gossypiifoliaIpomoea pes-capraemasterThesisCNPQ::CIENCIAS DA SAUDE::FARMACIA