The Alzheimer susceptibility gene BIN1 induces isoform-dependent neurotoxicity through early endosome defects

Lambert, ErwanSaha, OrthisLandeira, Bruna SoaresFarias, Ana Raquel Melo deHermant, XavierCarrier, ArnaudPelletier, AlexandreGadaut, JohannaDavoine, LindsayDupont, CloéAmouyel, PhilippeBonnefond, AmélieLafont, FrankAbdelfettah, FaridaVerstreken, PatrikChapuis, JulienBarois, NicolasDelahaye, FabienDermaut, BartLambert, Jean‑CharlesCosta, Marcos RomualdoDourlen, Pierre2022-01-252022-01-252022-01-08LAMBERT, Erwan; SAHA, Orthis; LANDEIRA, Bruna Soares. FARIAS, Ana Raquel Melo de. HERMANT, Xavier. CARRIER, Arnaud. PELLETIER, Alexandre. GADAUT, Johanna. DAVOINE, Lindsay. DUPONT, Cloé. AMOUYEL, Philippe. BONNEFOND, Amélie. LAFONT, Frank. ABDELFETTAH, Farida. VERSTREKEN, Patrik. CHAPUIS, Julien. BAROIS, Nicolas. DELAHAYE, Fabien. DERMAUT, Bart. LAMBERT, Jean Charles. COSTA, Marcos Romualdo. DOURLEN, Pierre. The Alzheimer susceptibility gene BIN1 induces isoform-dependent neurotoxicity through early endosome defects. Acta Neuropathologica Communications, [S. l.], v. 10, n. 1, p. 4, jan. 2022. Doi: 10.1186/s40478-021-01285-5. Disponível em: https://actaneurocomms.biomedcentral.com/articles/10.1186/s40478-021-01285-5. Acesso em: 25 jan. 2022.https://repositorio.ufrn.br/handle/123456789/45713Attribution 3.0 Brazilhttp://creativecommons.org/licenses/by/3.0/br/BIN1 isoformsNeurodegenerationEarly endosomeAlzheimer’s diseaseDrosophilaHuman induced neuronsThe Alzheimer susceptibility gene BIN1 induces isoform-dependent neurotoxicity through early endosome defectsarticlehttps://doi.org/10.1186/s40478-021-01285-5