Lima, Adley Antonini Neves deSilva, Rita Yanka Pereira da2023-06-022023-06-022022-12-21SILVA, Rita Yanka Pereira da. Obtenção de micropartículas polímericas para veiculação de α, β-amirina: caracterização físico-química e avaliação de atividades biológicas in vitro. Orientador: Adley Antonini Neves de Lima. 2022. 62f. Dissertação (Mestrado em Ciências Farmacêuticas) - Centro de Ciências da Saúde, Universidade Federal do Rio Grande do Norte, Natal, 2022.https://repositorio.ufrn.br/handle/123456789/52591Triterpenoids have aroused the interest of the scientific community in recent years due to the use, in popular medicine, of natural complexes that contain these substances in their composition. Among them, there is α, β-amyrin, a pentacyclic triterpene that consists of an isomeric mixture of compounds with ursane and oleonane backbone. Some pharmacological activities have been reported, however, with no defined pharmacodynamic target. In addition, the low solubility in water hinders the absorption of the compound. In this work, polymeric microparticles with hydropropylmethylcellulose (HPMC) were developed to carry α, β-amyrin and the biological activity of inhibitor of α- glucosidase and pancreatic lipase, agonist of Liver X Receptor β (LXRβ) and antioxidant capacity was investigated. In addition, the physical-chemical characterization of the obtained systems was carried out. In it, the spectra obtained in the FTIR showed effective interaction between the active principle and the polymer; in the DR-X diffractograms, it was observed that the isolated active presents high crystallinity, but, when incorporated into the polymeric microparticles, this crystallinity reduced; Scanning Electron Microscopy (SEM), as well as DR-X, showed α, β-amyrin as a highly crystalline structure, with welldefined, long, needle-shaped crystals. When carried in the microparticles, the crystals, although still visible, were considerably reduced in size. The results of the lipase and α-glucosidase inhibition assay showed that the microparticles did not inhibit such enzymes, however, the agonist activity of the nuclear receptor LXRβ showed that the active ingredient exerts agonist activity on this receptor. More studies seeking to elucidate the targets through which α, β-amyrin exerts its effects must be carried out and other studies delving into its effect on the LXRβ receptor.TriterpenosAlfa-amirinaBeta-amirinaMicropartículas poliméricasLXRAlfa-glicosidasemasterThesisCNPQ::CIENCIAS DA SAUDE::FARMACIA