Oliveira, Antonio Manuel Gouveia deCunha, Marta Danielle de Almeida Pimenta2019-10-072019-10-072019-03-29CUNHA, Marta Danielle de Almeida Pimenta. Modelo farmacocinético populacional para a prevenção da toxicidade ao sulfato de magnésio em gestantes com pré-eclâmpsia . 2019. 72f. Dissertação (Mestrado em Ciências Farmacêuticas) - Centro de Ciências da Saúde, Universidade Federal do Rio Grande do Norte, Natal, 2019.https://repositorio.ufrn.br/jspui/handle/123456789/27798OBJECTIVES: To develop a population pharmacokinetic model considering individual patient characteristics aimed at an improved dose definition for the prevention of toxicity in pregnant women with pre-eclampsia (PE). METHODOLOGY: Prospective cohort of patients with preeclampsia administered magnesium sulfate. The patients (n = 111) received 4 g of magnesium sulphate intravenously followed by the hourly infusion of 1 g during 24 hours. Serum magnesium levels were measured in blood samples obtained before administration and 2,6,12 and 18 hour safter the initial dose and 4h after the end of the administration. Adverse reactions to magnesium sulphate were investigatedthroughactivesearch.Populationpharmacokineticparameterswere estimated using the Monolix software® 2018 Suite (Lixoft®, Antony, France). Demographic, clinical and laboratory variables were tested for significance. RESULTS: An one-compartment model was adopted. Patients with alower body weight and higher serum creatinine are more susceptible to magnesium toxicity. CONCLUSION: The population pharmacokinetics model proposes the adoption of individualized dosing schemes of magnesium sulfate based on creatinine and body weight in order to prevent toxicity manifestations.Acesso AbertoFarmacocinéticaPré-eclâmpsiaSulfato de magnésioReação adversaGestantemasterThesisCNPQ::CIENCIAS DA SAUDE::FARMACIA