Navegando por Autor "Almeida‑Filho, Daniel G."

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Memory corticalization triggered by REM sleep: mechanisms of cellular and systems consolidation
(2018-07-19) Almeida‑Filho, Daniel G.; Queiroz, Claudio Marcos Teixeira de; Ribeiro, Sidarta Tollendal Gomes
Once viewed as a passive physiological state, sleep is a heterogeneous and complex sequence of brain states with essential efects on synaptic plasticity and neuronal functioning. Rapid-eye-movement (REM) sleep has been shown to promote calcium-dependent plasticity in principal neurons of the cerebral cortex, both during memory consolidation in adults and during post-natal development. This article reviews the plasticity mechanisms triggered by REM sleep, with a focus on the emerging role of kinases and immediate-early genes for the progressive corticalization of hippocampus-dependent memories. The body of evidence suggests that memory corticalization triggered by REM sleep is a systemic phenomenon with cellular and molecular causes.

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