Navegando por Autor "Araujo, Draulio Barros de"

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Análise quantitativa do relato dos efeitos agudos da ayahuasca em voluntários saudáveis
(Universidade Federal do Rio Grande do Norte, 2021-04-16) Xavier, Júlia da Silva; Araujo, Draulio Barros de; Fontes, Fernanda Palhano Xavier de; Fontes, Fernanda Palhano Xavier de; Mota, Natália Bezerra
Uma das principais formas de acessar informações sobre o estado alterado de consciência com a utilização de psicodélicos, as ferramentas automatizadas da fala vêm ganhando notável importância. Tais ferramentas contribuem para resultados mais precisos e efetivos. Nesse estudo, foram analisados os relatos de experiência, com ayahuasca ou placebo, de 40 voluntários saudáveis através do uso de ferramentas automatizadas da fala e correlacionados com medidas da Hallucinogen Rating Scale (HRS). Os resultados mostraram diferenças significativas no conteúdo semântico dos discursos quando comparados os grupos ayahuasca e placebo. A análise mostrou aspectos notáveis no comportamento dos indivíduos considerando estados diferentes da consciência (com utilização de substância alucinógena pela ayahuasca ou com placebo) e indicam uma maior proporção de conteúdo afetivo para o grupo ayahuasca, enquanto que mostram maior conteúdo relacionado com sensações físicas para indivíduos do grupo placebo. Estes resultados corroboram com a permanência e intensificação da adoção de ferramentas automatizadas da fala indicativo de acesso a informações mais confiáveis e seguras com a utilização de psicoativos.
Brazilian psychedelic science and the frontiers of psychiatry
(2024-10) Araujo, Draulio Barros de; Sanchez, Tiago Arruda; Ribeiro, Sidarta Tollendal Gomes
The use of psychedelic substances has intrigued, benefited, and challenged humanity for millennia. These substances, found regularly in nature, are known to induce non-ordinary states of consciousness. They provide heightened sensory, emotional and cognitive experiences, which include augmented visual imagery, changes in thought, mood, and awareness, perception of space-time and reality and, in many cases, profound insights, and mystical experiences. Throughout history, many indigenous populations around the world developed the use of these substances, especially as a vital component of healing. From the Amazon, for example, Ayahuasca emerged, a drink made from the combination of two plants, used ancestrally by shamans to promote physical and psychological healing. Likewise, indigenous populations in North America, such as the Navajo, retain the ancestral use of the peyote cactus as sacred medicine, while indigenous populations such as the Mazatecs of Mexico used psilocybin-containing mushrooms in their healing rituals
Emotion regulation effects of Ayahuasca in experienced subjects during implicit aversive stimulation: an fMRI study
(Elsevier BV, 2023-11) Sanchez, Tiago Arruda; Ramos, Lucas Rego; Araujo, Felipe; Schenberg, Eduardo Ekman; Yonamine, Mauricio; Lobo, Isabela; Araujo, Draulio Barros de; Luna, Luis Eduardo
Ethnopharmacological relevance: Ayahuasca is a beverage used in Amazonian traditional medicine and it has been part of the human experience for millennia as well as other different psychoactive plants. Although Ayahuasca has been proposed as potentially therapeutic as an anxiolytic and antidepressant, whilst no studies have been carried out so far investigating their direct effect on brain emotional processing. Aim of the study: This study aimed to measure the emotional acute effect of Ayahuasca on brain response to implicit aversive stimulation using a face recognition task in functional magnetic resonance imaging (fMRI). Materials and methods: Nineteen male experienced Ayahuasca users participated in this study in two fMRI sessions before and after 50 min of the Ayahuasca ingestion. Subjects were presented with pictures of neutral (A) and aversive (B) (fearful or disgusted) faces from the Pictures of Facial Affect Series. Subjects were instructed to identify the gender of the faces (gender discrimination task) while the emotional content was implicit. Subjective mood states were also evaluated before Ayahuasca intake and after the second fMRI session, using a visual analogue mood scale (VAMS). Results: During the aversive stimuli, the activity in the bilateral amygdala was attenuated by Ayahuasca (qFDR<0.05). Furthermore, in an exploratory analysis of the effects after intake, Ayahuasca enhances the activation bilaterally in the insula, as well as in the right dorsolateral prefrontal cortex (qFDR<0.05). In the psychometric VAMS scale, subjects reported attenuation of both anxiety and mental sedation (p < 0.01) during acute effects. Conclusions: Together, all reported results including neuroimaging, behavioral data and psychometric self-report suggest that Ayahuasca can promote an emotion regulation mechanism in response to aversive stimuli with corresponding improved cognition including reduced anxiety and mental sedation
In vivo mapping of pharmacologically induced functional reorganization onto the human brain’s neurotransmitter landscape
(American Association for the Advancement of Science (AAAS), 2023-06) Luppi, Andrea I.; Hansen, Justine Y.; Adapa, Ram; Carhart-Harris, Robin L.; Roseman, Leor; Timmermann, Christopher; Golkowski, Daniel; Ranft, Andreas; Ilg, Rüdiger; Jordan, Denis; Bonhomme, Vincent; Vanhaudenhuyse, Audrey; Demertzi, Athena; Jaquet, Oceane; Bahri, Mohamed Ali; Alnagger, Naji L. N.; Cardone, Paolo; Peattie, Alexander R. D.; Manktelow, Anne E.; Araujo, Draulio Barros de; Sensi, Stefano L.; Owen, Adrian M.; Naci, Lorina; Menon, David K.; Misic, Bratislav; Stamatakis, Emmanuel A.
To understand how pharmacological interventions can exert their powerful effects on brain function, we need to understand how they engage the brain’s rich neurotransmitter landscape. Here, we bridge microscale molecular chemoarchitecture and pharmacologically induced macroscale functional reorganization, by relating the regional distribution of 19 neurotransmitter receptors and transporters obtained from positron emission tomography, and the regional changes in functional magnetic resonance imaging connectivity induced by 10 different mind-altering drugs: propofol, sevoflurane, ketamine, lysergic acid diethylamide (LSD), psilocybin, N,N-Dimethyltryptamine (DMT), ayahuasca, 3,4-methylenedioxymethamphetamine (MDMA), modafinil, and methylphenidate. Our results reveal a many-to-many mapping between psychoactive drugs’ effects on brain function and multiple neurotransmitter systems. The effects of both anesthetics and psychedelics on brain function are organized along hierarchical gradients of brain structure and function. Last, we show that regional co-susceptibility to pharmacological interventions recapitulates co-susceptibility to disorder-induced structural alterations. Collectively, these results highlight rich statistical patterns relating molecular chemoarchitecture and drug-induced reorganization of the brain’s functional architecture
Information parity increases on functional brain networks under influence of a psychedelic substance
(IOP Publishing, 2023-03) Viol, Aline; Mohan, Madras Viswanathan Gandhi; Soldatkina, Oleksandra; Fontes, Fernanda Palhano Xavier de; Ventura, Heloisa Helena dos Santos Onias; Araujo, Draulio Barros de; Hövel, Philipp
The physical basis of consciousness is one of the most intriguing open questions that contemporary science aims to solve. By approaching the brain as an interactive information system, complex network theory has greatly contributed to understand brain process in different states of mind. We study a non-ordinary state of mind by comparing resting-state functional brain networks of individuals in two different conditions: before and after the ingestion of the psychedelic brew Ayahuasca. In order to quantify the functional, statistical symmetries between brain region connectivity, we calculate the pairwise information parity of the functional brain networks. Unlike the usual approach to quantitative network analysis that considers only local or global scales, information parity instead quantifies pairwise statistical similarities over the entire network structure. We find an increase in the average information parity on brain networks of individuals under psychedelic influences. Notably, the information parity between regions from the limbic system and frontal cortex is consistently higher for all the individuals while under the psychedelic influence. These findings suggest that the resemblance of statistical influences between pair of brain regions activities tends to increase under Ayahuasca effects. This could be interpreted as a mechanism to maintain the network functional resilience
Low-dose LSD and the stream of thought: Increased Discontinuity of Mind, Deep Thoughts and abstract flow
(Springer Science and Business Media LLC, 2021-10-28) Wießner, Isabel; Falchi, Marcelo; Fontes, Fernanda Palhano Xavier de; Maia, Lucas Oliveira; Feilding, Amanda; Ribeiro, Sidarta Tollendal Gomes; Mota, Natália Bezerra; Araujo, Draulio Barros de; Tófoli, Luís Fernando
Rationale: Stream of thought describes the nature of the mind when it is freely roaming, a mental state that is continuous and highly dynamic as in mind-wandering or free association. Classic serotonergic psychedelics are known to profoundly impact perception, cognition and language, yet their influence on the stream of thought remains largely unexplored. Objective: To elucidate the effects of LSD on the stream of thought. Methods: In a randomized, double-blind, placebo-controlled, crossover study, 24 healthy participants received 50 μg lysergic acid diethylamide (LSD) or inactive placebo. Mind-wandering was measured by the Amsterdam Resting State Questionnaire (ARSQ), free association by the Forward Flow Task (FFT) for three seed word types (animals, objects, abstract words). ARSQ and FFT were assessed at +0 h, +2 h, +4 h, +6 h, +8 h and +24 h after drug administration, respectively. Results: LSD, compared to placebo, induced different facets of mind-wandering we conceptualized as “chaos” (Discontinuity of Mind, decreased Sleepiness, Planning, Thoughts under Control, Thoughts about Work and Thoughts about Past), “meaning” (Deep Thoughts, Not Sharing Thoughts) and “sensation” (Thoughts about Odours, Thoughts about Sounds). LSD increased the FFT for abstract words reflecting an “abstract flow” under free association. Overall, chaos was strongest pronounced (+2 h to +6 h), followed by meaning (+2 h to +4 h), sensation (+2 h) and abstract flow (+4 h). Conclusions: LSD affects the stream of thought within several levels (active, passive), facets (chaos, meaning, sensation, abstractness) and time points (from +2 h to +6 h). Increased chaos, meaning and abstract flow at +4 h indicate the utility of a late therapeutic window in psycholytic therapy.
Moderators of ayahuasca’s biological antidepressant action
(Frontiers Media SA, 2022-12) Sousa Júnior, Geovan Menezes de; Tavares, Vagner Deuel de Oliveira; Galvão, Ana Cecília de Menezes; Almeida, Raíssa Nóbrega de; Fontes, Fernanda Palhano Xavier de; Soares, Bruno Lobão; Freire, Fúlvio Aurélio de Morais; Nunes, Emerson Arcoverde; Oliveira, João Paulo Maia de; Perkins, Daniel; Sarris, Jerome; Araujo, Draulio Barros de; Coelho, Nicole Leite Galvão
Introduction: The understanding of biological responses to psychedelics with antidepressant potential is imperative. Here we report how a set of acute parameters, namely emotional (depressive symptoms), cognitive (psychedelic experience), and physiological (salivary cortisol), recorded during an ayahuasca dosing session, modulated serum brain-derived neurotrophic factor (BDNF), serum cortisol (SC), serum interleukin 6 (IL-6), plasma C-reactive protein (CRP), and salivary cortisol awakening response (CAR). Methods: Results were analyzed 2 days after the psychedelic intervention (ayahuasca) versus placebo in both patients with treatment-resistant depression and healthy volunteers. These measures were assessed as part of a randomized double-blinded, placebo-controlled trial (n = 72). Results: Results revealed that larger reductions of depressive symptoms during the dosing session significantly moderated higher levels of SC in patients. Whereas lesser changes in salivary cortisol levels during the ayahuasca intervention were related to higher BDNF levels in patients with a larger clinical response in the reduction in depressive symptoms. No moderator was found for patient's CAR, IL-6, and CRP responses to ayahuasca and for all biomarker responses to ayahuasca in healthy controls and in the placebo group. Discussion: In summary, some specific emotional and physiological parameters during experimental ayahuasca session were revealed as critical moderators of the improvement of major depression biomarkers, mainly BDNF and SC two days after ayahuasca intake. These findings contribute to paving the way for future studies investigating the biological antidepressant response to psychedelic therapy
Non-judgement prevents positive correlation between observe and state anxiety in healthy non-meditators
(2022) Sousa Júnior, Geovan Menezes de; Araújo, Geissy Lainny de Lima; Araujo, Draulio Barros de; Sousa, Maria Bernardete Cordeiro de
Background: In this paper, we investigate how dispositional attentional quality is present, and its correlation with measures of well-being, in university student’s naïve in meditation practice. Methods: A total of 40 students (20 females) were asked to fill self-reported measures of stress, anxiety, affect, and dispositional mindfulness. Results: Negative correlations between some mindfulness facets and perceived stress, anxiety, and negative affect were found. The Non-judgement facet moderated the relationship between Observe and state anxiety, in which mild and high non-judgement levels prevent their positive relationship. Conclusion: Attentional quality in non-meditating university students seem to be important in regulating the ongoing experience of anxiety
Nootropic effects of LSD: Behavioral, molecular and computational evidence
(Elsevier BV, 2022-06-19) Ornelas, Isis M; Silva, Felipe Augusto Cini da; Wießner, Isabel; Marcos, Encarni; Araujo, Draulio Barros de; Goto-Silva, Livia; Nascimento, Juliana; Silva, Sérgio Ruschi Bergamachi; Costa, Marcelo N; Falchi, Marcelo; Olivieri, Rodolfo; Fontes, Fernanda Palhano Xavier de; Sequerra, Eduardo Bouth; Martins-de-Souza, Daniel; Feilding, Amanda; Costa, César Rennó; Tófoli, Luis Fernando; Rehen, Stevens K; Ribeiro, Sidarta Tollendal Gomes
The therapeutic use of classical psychedelic substances such as d-lysergic acid diethylamide (LSD) surged in recent years. Studies in rodents suggest that these effects are produced by increased neural plasticity, including stimulation of the mTOR pathway, a key regulator of metabolism, plasticity, and aging. Could psychedelic-induced neural plasticity be harnessed to enhance cognition? Here we show that LSD treatment enhanced performance in a novel object recognition task in rats, and in a visuo-spatial memory task in humans. A proteomic analysis of human brain organoids showed that LSD affected metabolic pathways associated with neural plasticity, including mTOR. To gain insight into the relation of neural plasticity, aging and LSD-induced cognitive gains, we emulated the experiments in rats and humans with a neural network model of a cortico-hippocampal circuit. Using the baseline strength of plasticity as a proxy for age and assuming an increase in plasticity strength related to LSD dose, the simulations provided a good fit for the experimental data. Altogether, the results suggest that LSD has nootropic effects
Pathophysiology of major depression by clinical stages
(Frontiers Media SA, 2021-08-05) Galvão, Ana Cecília de Menezes; Almeida, Raíssa Nobrega; Sousa Júnior, Geovan Menezes de; Miguel, Mario André Leocadio; Fontes, Fernanda Palhano Xavier de; Araujo, Draulio Barros de; Soares, Bruno Lobão; Oliveira, João Paulo Maia de; Nunes, Emerson Arcoverde; Hallak, Jaime Eduardo Cecilio; Schuch, Felipe Barreto; Sarris, Jerome; Galvão-Coelho, Nicole Leite
The comprehension of the pathophysiology of the major depressive disorder (MDD) is essential to the strengthening of precision psychiatry. In order to determine the relationship between the pathophysiology of the MDD and its clinical progression, analyzed by severity of the depressive symptoms and sleep quality, we conducted a study assessing different peripheral molecular biomarkers, including the levels of plasma C-reactive protein (CRP), serum mature brain-derived neurotrophic factor (mBDNF), serum cortisol (SC), and salivary cortisol awakening response (CAR), of patients with MDD (n = 58) and a control group of healthy volunteers (n = 62). Patients with the first episode of MDD (n = 30) had significantly higher levels of CAR and SC than controls (n = 32) and similar levels of mBDNF of controls. Patients with treatment-resistant depression (TRD, n = 28) presented significantly lower levels of SC and CAR, and higher levels of mBDNF and CRP than controls (n = 30). An increased severity of depressive symptoms and worse sleep quality were correlated with levels low of SC and CAR, and with high levels of mBDNF. These results point out a strong relationship between the stages clinical of MDD and changes in a range of relevant biological markers. This can assist in the development of precision psychiatry and future research on the biological tests for depression
Potential biomarkers of major depression diagnosis and chronicity
(2021-09-29) Galvão, Ana Cecília de Menezes; Almeida, Raissa Nobrega; Sousa Júnior, Geovan Menezes de; Leocadio-Miguel, Mário André; Fontes, Fernanda Palhano Xavier de; Araujo, Draulio Barros de; Lobão-Soares, Bruno; Maia-de-Oliveira, João Paulo; Nunes, Emerson Arcoverde; Hallak, Jaime Eduardo Cecilio; Sarris, Jerome; Galvão-Coelho, Nicole Leite
Molecular biomarkers are promising tools to be routinely used in clinical psychiatry. Among psychiatric diseases, major depression disorder (MDD) has gotten attention due to its growing prevalence and morbidity. We tested some peripheral molecular parameters such as serum mature Brain-Derived Neurotrophic Factor (mBDNF), plasma C-Reactive Protein (CRP), serum cortisol (SC), and the salivary Cortisol Awakening Response (CAR), as well as the Pittsburgh sleep quality inventory (PSQI), as part of a multibiomarker panel for potential use in MDD diagnosis and evaluation of disease’s chronicity using regression models, and ROC curve. For diagnosis model, two groups were analyzed: patients in the first episode of major depression (MD: n = 30) and a healthy control (CG: n = 32). None of those diagnosis models tested had greater power than Hamilton Depression Rating Scale-6. For MDD chronicity, a group of patients with treatment-resistant major depression (TRD: n = 28) was tested across the MD group. The best chronicity model (p < 0.05) that discriminated between MD and TRD included four parameters, namely PSQI, CAR, SC, and mBDNF (AUC ROC = 0.99), with 96% of sensitivity and 93% of specificity. These results indicate that changes in specific biomarkers (CAR, SC, mBDNF and PSQI) have potential on the evaluation of MDD chronicity, but not for its diagnosis. Therefore, these findings can contribute for further studies aiming the development of a stronger model to be commercially available and used in psychiatry clinical practice
Preliminary evidence of links between ayahuasca use and the corpus callosum
(Frontiers Media SA, 2022-10) Simonsson, Otto; Bouso, José Carlos; Kurth, Florian; Araujo, Draulio Barros de; Gaser, Christian; Riba, Jordi; Luders, Eileen
Background: Recent research suggests that ayahuasca and its alkaloid-containing ingredients may be helpful in the treatment and prevention of certain movement and neurodegenerative disorders. However, such research is still in its infancy and more studies in normative samples seem necessary to explore effects of ayahuasca on clinically relevant brain structures, such as the corpus callosum. Aims: The purpose of the present study was to investigate links between ayahuasca use and callosal structure in a normative sample. Methods: Using structural imaging data from 22 ayahuasca users and 22 matched controls we compared the thickness of the corpus callosum between both groups at 100 equidistant points across the entire midsagittal surface. In addition, we investigated point-wise correlations between callosal thickness and the number of past ayahuasca sessions. Results: The corpus callosum was significantly thicker within the isthmus in the ayahuasca group than in the control group. There was also a significant positive correlation between callosal thickness and the number of past ayahuasca sessions within the rostral body, albeit none of these effects survived corrections for multiple comparisons. No region was significantly thicker in the control than in the ayahuasca group, and no callosal region was negatively linked to ayahuasca use, even at uncorrected significance thresholds. Conclusion: This study provides preliminary evidence of links between ayahuasca use and the corpus callosum. However, future studies need to replicate these findings, preferably using larger sample sizes and ideally also utilizing longitudinal research designs, to draw any practical conclusion and offer implications for follow-up clinical research
Prophylactic action of ayahuasca in a non-human primate model of depressive-like behavior
(Frontiers Media SA, 2022-11) Grilo, Maria Lara Porpino de Meiroz; Sousa, Geovan Menezes de; Mendonça, Lilían Andrade Carlos de; Soares, Bruno Lobão; Sousa, Maria Bernardete Cordeiro de; Fontes, Fernanda Palhano Xavier de; Araujo, Draulio Barros de; Perkins, Daniel; Hallak, Jaime Eduardo Cecilio; Coelho, Nicole Leite Galvão
Observational studies of long-term users of ayahuasca, an Amazonian psychedelic brew, suggest an increase in resilience via improvements in emotion and cognition. Ayahuasca has also demonstrated clinical antidepressant effects in human and animal studies; however, its potential prophylactic action in depression has not been previously studied. Therefore, this experimental study sought to evaluate the potential prophylactic effects of repeated and long-term ayahuasca use, via the modulation of resilience, in a non-human primate animal model, Callithrix jacchus, subjected to a protocol for induction of depressive-like behavior. For the formation of the study groups, some juvenile marmosets were kept in their family groups (GF = 7), while for the two experimental groups, the animals were removed from the family and kept socially isolated. Then, part of the isolated animals made up the group in which ayahuasca was administered (AG, n = 6), while for others, no intervention was made (IG, n = 5). AG animals took ayahuasca (1.67 mL/300g body weight) at weeks 4 (before isolation), 8, and 12 (during isolation) of the study. More adaptive stress response was observed for the AG when compared to the IG. The AG showed higher cortisol reactivity and fecal cortisol levels than IG, while both measures were similar to FG. Moreover, AG animals showed no signs of anhedonia and no increase in chronic stress-related behaviors, which were expressed by the IG. Thus, ayahuasca seems to promote the expression of resilient responses, indicating a prophylactic action, buffering the emergence of depressive-like behaviors and cortisol alterations associated with major depression. These results are encouraging for further research on the prophylactic use of psychedelics to prevent psychopathologies associated with chronic stress
A quantitative textual analysis of the subjective effects of ayahuasca in naïve users with and without depression
(Springer Science and Business Media LLC, 2023-11) Cruz, Lucas; Bienemann, Bheatrix; Fontes, Fernanda Palhano Xavier de; Tófoli, Luís Fernando; Araujo, Draulio Barros de; Mograbi, Daniel Correa
Ayahuasca is a brew with psychoactive properties that has been used as an entheogen for centuries, with more recent studies suggesting it is a promising treatment for some clinical disorders. Although there is an emerging scientific literature on its effects, to the best of our knowledge no study has explored the self-reported experiences of first-time ayahuasca users with quantitative textual analysis tools. Accordingly, the current study aimed to analyze the subjective experience of naive individuals with depression and healthy controls after consuming ayahuasca. For this purpose, responses from a subsample of participants from a previous clinical trial to open-ended questions regarding their experience with ayahuasca underwent textual analysis. Data from nine patients with treatment-resistant depression and 20 healthy individuals were included, and quantitative textual analysis was performed using IRaMuTeQ 0.7 alpha 2 and R 3.1.2. The analysis identified five clusters: alterations in the state of consciousness, cognitive changes, somatic alterations, auditory experiences, and visual perceptual content. Additionally, findings suggest specific features of the experience of people with depression with ayahuasca, such as increased aversive bodily reactions. The results are consistent with previous findings indicating central axes of the psychedelic experience, and may inform therapeutic approaches using ayahuasca
The DEA report on ayahuasca risks: “Science” in service of prohibition?
(Akademiai Kiado Zrt, 2023-06) Labate, Beatriz Caiuby; Ermakova, Anna O.; Sloshower, Jordan; Coelho, Nicole Leite Galvão; Fontes, Fernanda Palhano Xavier de; Antunes, Henrique Fernandes; Assis, Glauber Loures de; Cavnar, Clancy; Araujo, Draulio Barros de; Ribeiro, Sidarta Tollendal Gomes
On February 2023, the Drug Enforcement Administration (DEA) released a document to the legal team representing the Church of the Eagle and the Condor (“CEC”). This disclosure came two years after the church, in conjunction with Chacruna Institute, submitted two FOIA requests to the DEA and the Department of Justice requesting all records pertaining to ayahuasca. This report, titled “Ayahuasca: Risks to Public Health and Safety,” was issued in July 2020. In the present article, we challenge a number of claims made in the DEA report and highlight significant factual omissions, theoretical biases, and misinterpretations of existing data. We will demonstrate that the DEA report severely downplays the safety profile and therapeutic potential of ayahuasca and overemphasizes the risks. It also fails to include current research on ayahuasca demonstrating its potential benefits
The impact of a brief mindfulness training on interoception: A randomized controlled trial
(Public Library of Science (PLoS), 2022-09-07) Araujo, Geissy Lainny de Lima; Sousa Júnior, Geovan Menezes de; Mendes, Thatiane Maria Almeida Silveira; Demarzo, Marcelo; Farb, Norman; Araujo, Draulio Barros de; Sousa, Maria Bernardete Cordeiro de
Interoception is a collection of different representations of signals originating within the body. The way of perceiving these signals seems to be related to both emotion regulation and dysregulation, and its dysfunction is implicated across a variety of affective disorders. There is a growing body of research investigating the relationship between mindfulness meditation practices and interoception showing an increase in interoceptive processes with regular training. In this study, we assessed the effects of a three-day mindfulness training on interoceptive accuracy and sensibility in a young healthy adult sample. Moreover, we also performed a mediation analysis on interoceptive sensibility and anxiety. Healthy participants (n = 40) naive to mindfulness practices were randomized to a brief mindfulness training (MT) (n = 20, females = 10) or to an active control group (n = 20, females = 10). Participants were assessed before and after the 3-days intervention for both groups on measures of interoception and anxiety in a modified intention-to-treat approach. The brief mindfulness training group increased interoceptive sensibility while active control had no effects on this variable. Five out of eight subdomains of interoceptive sensibility were significantly improved after mindfulness training. There was no significant difference in interoceptive accuracy after training. The effect of a brief mindfulness training on interoceptive sensibility mediated changes in the anxiety state. To date, this is the first study showing a plausible mechanism of a brief mindfulness training to explain the anxiolytic effects of meditation practices

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Navegando por Autor "Araujo, Draulio Barros de"