Navegando por Autor "Bona, Mariana Duarte"
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TCC Intervenções não farmacológicas para a redução do peso melhoram ou não a condição da barreira intestinal?(Universidade Federal do Rio Grande do Norte, 2023-06-28) Lima, Andressa Shaine de Araújo; Maciel, Bruna Leal Lima; Bona, Mariana Duarte; Maciel, Bruna Leal Lima; Bona, Mariana Duarte; Campos, Ana Carolina CostaA obesidade é uma doença crônica que desencadeia uma série de consequências metabólicas e torna-se um fator de risco para outras comorbidades, além de afetar negativamente diversos mecanismos fisiológicos, dentre eles, a função de barreira intestinal, a permeabilidade e a saúde da microbiota. Objetivou-se realizar uma revisão integrativa contendo os estudos mais recentes com intervenções não farmacológicas para a redução do peso e sua relação com a barreira intestinal. A presente revisão foi norteada com a questão: “Intervenções não farmacológicas para a redução do peso melhoram ou não a condição de barreira intestinal?”. As buscas foram realizadas nas bases de dados Pubmed, Scopus, LILACS, Embase e ScienceDirect, iniciaram em Abril de 2021 e finalizaram em Fevereiro de 2023, utilizando os termos “weight reduction”, “weight loss”, “obesity”, “intestinal permeability” de acordo o MeSH, sendo os operadores booleanos “AND” e “OR”. Os critérios de inclusão foram os estudos clínicos realizados em humanos a partir do ano de 2015 a 2023, sendo selecionados, ao final, 4 artigos. Na obesidade, o intestino apresenta alterações na função da barreira intestinal e, nos estudos, foram analisadas as intervenções sendo dietas com restrição calórica, cirurgia bariátrica, uso de simbióticos e bebida de farinha de Yacon. Foi observado que a relação entre a melhora da função de barreira intestinal e a intervenção utilizada está significativamente ligada ao grau da perda de peso gerada no indivíduo e que essa mudança apresenta também uma maior diversidade da microbiota intestinal e diminuição de marcadores de inflamação que pioram a barreira intestinal.Artigo Intestinal barrier function in obesity with or without metabolic syndrome: a systematic review protocol(BMJ Open, 2021-05) Maciel, Bruna Leal Lima; Bona, Mariana Duarte; Torres, Carlos Henrique de Medeiros; Lima, Severina Carla Vieira Cunha; Lima, Aldo Angelo MoreiraIntroduction Intestinal barrier function is dependent on the structure and function of intestinal epithelial cells and paracellular pathway. The derangement of the intestinal barrier function can originate from conditions involving local and systemic chronic inflammation and metabolic diseases such as obesity and metabolic disorders. This study aims to describe a systematic review protocol investigating if obesity with or without metabolic syndrome is associated with an altered intestinal barrier function. Methods and analysis This protocol is guided by the Preferred Reporting Items for Systematic Reviews and Meta-Analyses Protocols. The databases to be searched are PubMed, Embase, Scopus, Science Direct and Web of Science. The systematic review will include original articles with adults and the elderly, who present obesity with or without metabolic syndrome, that address the intestinal barrier function. Two independent reviewers will perform study selection, data extraction and methodological quality assessment. Key information will be tabulated and a narrative synthesis will be conducted. The Grading of Recommendation, Assessment, Development and Evaluation framework will be used to assess the quality of evidence concerning the associations between intestinal barrier function and obesity with or without metabolic syndrome. The present protocol will assist in producing a systematic review that addresses if obesity with or without metabolic syndrome alters intestinal barrier function. Ethics and dissemination No ethical statement will be required. The results will be disseminated through a peerreviewed publication and conference presentationsArtigo Intestinal barrier permeability in obese individuals with or without metabolic syndrome: a systematic review(Nutrients, 2022) Morais, Ana Heloneida de Araújo; Bona, Mariana Duarte; Torres, Carlos Henrique de Medeiros; Lima, Severina Carla Vieira Cunha; Lima, Aldo Ângelo Moreira; Maciel, Bruna Leal Lima; https://orcid.org/0000-0002-6460-911XAltered intestinal barrier permeability has been associated with obesity and its metabolic and inflammatory complications in animal models. The purpose of this systematic review is to assess the evidence regarding the association between obesity with or without Metabolic Syndrome (MetS) and alteration of the intestinal barrier permeability in humans. A systematic search of the studies published up until April 2022 in Latin America & Caribbean Health Sciences Literature (LILACS), PubMed, Scopus, Embase, and ScienceDirect databases was conducted. The methodological quality of the studies was assessed using the Newcastle–Ottawa scale (NOS) and the Agency for Healthcare Research and Quality (AHRQ) checklist. The Grading of Recommendations Assessment, Develop ment and Evaluation (GRADE) framework was used to assess the quality of the evidence. Eight studies were included and classified as moderate to high quality. Alteration of intestinal barrier per meability was evaluated by zonulin, lactulose/mannitol, sucralose, sucrose, lactulose/L-rhamnose, and sucralose/erythritol. Impaired intestinal barrier permeability measured by serum and plasma zonulin concentration was positively associated with obesity with MetS. Nonetheless, the GRADE assessment indicated a very low to low level of evidence for the outcomes. Thus, clear evidence about the relationship between alteration of human intestinal barrier permeability, obesity, and MetS was not found