Navegando por Autor "Cunha, Aline Tuane Oliveira"
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Artigo Effects of vitamin D supplementation on fasting glucose, dyslipidemia, blood pressure, and abdominal obesity among patients with metabolic syndrome: a protocol for systematic review and meta-analysis of randomized controlled trials(Systematic Reviews, 2020-08) Evangelista, Karine Cavalcanti Maurício de Sena; Aquino, Séphora Louyse Silva; Cunha, Aline Tuane Oliveira; Lima, Josivan Gomes; Oliveira, Antonio Gouveia; Cobucci, Ricardo Ney; Pedrosa, Lucia Fatima CamposBackground: Vitamin D deficiency can play a role in extraskeletal functions that are involved with a set of risk factors associated with metabolic syndrome (MetS). The purpose of this review is to investigate the impact of vitamin D supplementation on fasting glucose, dyslipidemia, blood pressure, and abdominal obesity among patients with MetS. Methods: EMBASE, Medline, Web of Science, Lilacs, the Cochrane Central Register of Controlled Trials, clinicaltrials.gov databases, and grey literature will be systematically searched for randomized controlled trials (RCTs) of vitamin D supplementation compared with placebo, through December 2020. We will include in the study patients with MetS diagnosed by the criteria set forth by the National Cholesterol Education Program Adult Treatment Panel III or the International Diabetes Federation. The effect of oral vitamin D supplementation on lipid profile improvement (triglycerides, high-density lipoprotein cholesterol—HDL-C) is this review’s primary outcome. The systematic review will be performed following the Preferred Reporting Items for Systematic Reviews and MetaAnalyses (PRISMA) guidelines. The study screening, data extraction, and quality assessment will be fulfilled by two independent reviewers according to the Cochrane Risk of Bias tool (RoB 2.0). The results of the systematic review will be provided according to the type of intervention, characteristics of the target population, the methods of measurement of vitamin D, the calculated vitamin D concentrations, types of biological samples, and types of outcomes. Meta-analyses will be conducted where appropriate. The Cochran’s Q test and the I 2 -heterogeneity test will be used to assess the presence of heterogeneity and whether the fixed or the random-effects model would be appropriate for combining study results using the inverse variance method or the DerSimonian-Lair method, respectively. Publication bias will be evaluated using funnel plots and Egger’s and Begg’s tests. The strength of the evidence will be assessed according to the Grading of Recommendations Assessment, Development, and Evaluation (GRADE). Discussion: This systematic review will assess the effects of vitamin D supplementation on fasting glucose and triglyceride levels, waist circumference and mean blood pressure, and HDL-C among individuals with MetS. These findings may assist with decision-making within a clinical settingArtigo Frequency of metabolic syndrome and associated factors in institutionalized elderly individuals(Clinical Interventions in Aging, 2018) Lima, Severina Carla Vieira Cunha; Sales, Marcia Cristina; Oliveira, Larissa Praça; Liberalino, Laura Camila Pereira; Cunha, Aline Tuane Oliveira; Lemos, Telma Maria Araujo Moura; Lima, Kenio Costa; Evangelista, Karine Cavalcanti Mauricio Sena; Pedrosa, Lucia Fatima Campos; Sousa, Sara estefani soares; https://orcid.org/0000-0001-8268-1986Introduction: Population aging generally accompanies an increase in chronic noncommunicable diseases, such as metabolic syndrome (MS). Nursing homes have provided a solution for the decreased ability of elderly individuals for self-care and familial difficulties in meeting the health care needs of elderly individuals. Purpose: The aim of the present study was to determine the frequency of MS and its associated factors in elderly individuals living in nursing homes. Patients and methods: This cross-sectional study was conducted with 202 institutionalized elderly individuals. MS was diagnosed according to the National Cholesterol Education Program – Adult Treatment Panel III criteria. Sociodemographic, clinical, and lifestyle factors were assessed to verify their association with MS by logistic regression. Results: The MS frequency was 29.2%. The most frequent MS components were low high-density lipoprotein cholesterol level (63.9%) and abdominal obesity (42.7%). Factors associ-ated with MS were female sex (prevalence ratio [PR]=2.16; 95% CI, 1.04–4.49), age-adjusted institutionalization time .50% (PR=2.38, 95% CI, 1.46–3.88), and high concentrations of interleukin-6 (PR=2.01; 95% CI, 1.21–3.32) and tumor necrosis factor-α (PR=1.70; 95% CI, 1.05–2.77). Moreover, it was verified that the likelihood of having MS was 1.85-fold higher (95% CI, 1.11–3.10) in the group with a diet characterized by very high energy, very low fat, and high dietary fiber. Conclusion: The occurrence of MS in institutionalized elderly individuals was higher in females, and individuals with longer age-adjusted institutionalization time, higher concentrations of immunologic biomarkers, and a dietary intake consisting of higher energy and fiber and lower total fat. The results of the study are useful for guiding health care programs aimed at institutionalized elderly individuals.Artigo Frequency of metabolic syndrome and associated factors in institutionalized elderly individuals(Clinical Interventions in Aging, 2018-11) Evangelista, Karine Cavalcanti Maurício de Sena; Sales, Marcia; Oliveira, Larissa Praça; Liberalino, Laura Camila Pereira; Cunha, Aline Tuane Oliveira; Sousa, Sara Estefani Soares; Lemos, Telma Maria Araujo Moura; Lima, Severina Carla Vieira Cunha; Lima, Kenio Costa; Pedrosa, Lucia Fatima CamposIntroduction: Population aging generally accompanies an increase in chronic noncommunicable diseases, such as metabolic syndrome (MS). Nursing homes have provided a solution for the decreased ability of elderly individuals for self-care and familial difficulties in meeting the health care needs of elderly individuals. Purpose: The aim of the present study was to determine the frequency of MS and its associated factors in elderly individuals living in nursing homes. Patients and methods: This cross-sectional study was conducted with 202 institutionalized elderly individuals. MS was diagnosed according to the National Cholesterol Education Program – Adult Treatment Panel III criteria. Sociodemographic, clinical, and lifestyle factors were assessed to verify their association with MS by logistic regression. Results: The MS frequency was 29.2%. The most frequent MS components were low high density lipoprotein cholesterol level (63.9%) and abdominal obesity (42.7%). Factors associ ated with MS were female sex (prevalence ratio [PR]=2.16; 95% CI, 1.04–4.49), age-adjusted institutionalization time .50% (PR=2.38, 95% CI, 1.46–3.88), and high concentrations of interleukin-6 (PR=2.01; 95% CI, 1.21–3.32) and tumor necrosis factor-α (PR=1.70; 95% CI, 1.05–2.77). Moreover, it was verified that the likelihood of having MS was 1.85-fold higher (95% CI, 1.11–3.10) in the group with a diet characterized by very high energy, very low fat, and high dietary fiber. Conclusion: The occurrence of MS in institutionalized elderly individuals was higher in females, and individuals with longer age-adjusted institutionalization time, higher concentrations of immunologic biomarkers, and a dietary intake consisting of higher energy and fiber and lower total fat. The results of the study are useful for guiding health care programs aimed at institutionalized elderly individualsArtigo Zinc status biomarkers and cardiometabolic risk factors in metabolic syndrome: a case control study(Nutrients, 2017-02-22) Lima, Severina Carla Vieira Cunha; Freitas, Erika Paula Silva; Cunha, Aline Tuane Oliveira; Aquino, Sephora Louyse Silva; Pedrosa, Lucia de Fátima Campos; Lima, Josivan Gomes de; Almeida, Maria das Graças; Evangelista, Karine Cavalcani Maurício Sena; https://orcid.org/0000-0001-8268-1986; https://orcid.org/0000-0002-5436-5115; https://orcid.org/0000-0002-1627-7018; https://orcid.org/0000-0001-9729-1243Metabolic syndrome (MS) involves pathophysiological alterations that might compromise zinc status. The aim of this study was to evaluate zinc status biomarkers and their associations with cardiometabolic factors in patients with MS. Our case control study included 88 patients with MS and 37 controls. We performed clinical and anthropometric assessments and obtained lipid, glycemic, and inflammatory profiles. We also evaluated zinc intake, plasma zinc, erythrocyte zinc, and 24-h urinary zinc excretion. The average zinc intake was significantly lower in the MS group (p < 0.001). Regression models indicated no significant differences in plasma zinc concentration (all p > 0.05) between the two groups. We found significantly higher erythrocyte zinc concentration in the MS group (p < 0.001) independent from co-variable adjustments. Twenty-four hour urinary zinc excretion was significantly higher in the MS group (p = 0.008), and adjustments for age and sex explained 21% of the difference (R2 = 0.21, p < 0.001). There were significant associations between zincuria and fasting blood glucose concentration (r = 0.479), waist circumference (r = 0.253), triglyceride concentration (r = 0.360), glycated hemoglobin concentration (r = 0.250), homeostatic model assessment—insulin resistance (r = 0.223), and high-sensitivity C-reactive protein concentration (r = 0.427) (all p < 0.05) in the MS group. Patients with MS had alterations in zinc metabolism mainly characterized by an increase in erythrocyte zinc and higher zincuria