Navegando por Autor "Egito, E. S. T."
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Artigo Magnetic Carriers: A Promising Device for Targeting Drugs Into the Human Body(Current Pharmaceutical Design, 2007) Silva, A. K. A.; Silva, É. L.; Carriço, Artur da Silva; Egito, E. S. T.Suboptimal disposition behavior of drugs requires innovative delivery approaches. Magnetic drug targeting seems to be a promising one. Magnetic particles develop magnetic polarization and magnetophoretic mobility, and because of such unique properties, these carriers may be eligible candidates for delivering drugs to specific locations within the body. Their special properties also allow other uses, such as those in magnetic separation, hyperthermia, and magnetic resonance imaging. This review focuses on a brief discussion of magnetic drug targeting, the properties and fate of magnetic carriers, the methods used to produce and characterize them, and their other uses in biotechnology.Artigo Monodisperse sodium oleate coated magnetite high susceptibility nanoparticles for hyperthermia applications(Elsevier B.V., 2014-08-13) Carriço, Artur da Silva; Araújo Neto, R. P.; Silva Freitas, E. L.; Carvalho, J. F.; Pontes, T. R. F.; Silva, K. L.; Damasceno, I. H. M.; Egito, E. S. T.; Dantas, Ana L.; Morales, Marco A.We report a simple and low cost methodology to synthesize sodium oleate coated magnetite nanoparticles for hyperthermia applications. The system consists of oleate coated magnetite nanoparticles with large susceptibility (1065 emu/gT), induced by the dipolar inter-particle interaction, with a magnetic core diameter in the 6 nm–12 nm size range. In aqueous medium, the nanoparticles agglomerate to form a monodisperse system, exhibiting a mean hydrodynamic diameter of 60.6 nm±4.1 nm, with a low average polydispersity index of 0.128±0.003, as required for intravenous applications. The system exhibits promising efficiency for magnetic hyperthermia, with a specific absorption rate of 14 W/g at a low field amplitude of 15.9 kA/m and frequency of 62 kHz. In a 50 mg/mL density in 1 mL, the temperature rises to 42.5 °C in 1.9 min.