Navegando por Autor "Ferreira, Marcelo Rodrigo Portela"
Agora exibindo 1 - 1 de 1
- Resultados por página
- Opções de Ordenação
Artigo Association between exposure to plasma mixture of essential and toxic elements and the lipid profile in institutionalized older adults(Journal of Trace Elements in Medicine and Biology, 2024-09) Evangelista, Karine Cavalcanti Maurício de Sena; Pacheco, Daniela Antunes; Campêlo, Angélica Lopes de Sousa; Sousa, Sara Estéfani Soares de; Sales, Márcia Cristina; Barbosa Júnior, Fernando; Lima, Kenio Costa; Ferreira, Marcelo Rodrigo Portela; Reis, Bruna Zavarize; Pedrosa, Lucia Fatima CamposBackground: Older adults have a progressive deficiency in the ability to detoxify chemical elements and are susceptible to dyslipidemia and changes in glycemic control. The objective was to evaluate the association of the mixture of essential and toxic elements in the plasma of institutionalized older adults and test the associations with lipid profile variables and glycemic control. Methods: Data were obtained from 149 Brazilian older adults aged ≥60 living in nursing homes (NH) in Natal, Brazil. The concentrations of sixteen chemical elements in plasma and lipid profile parameters and glycemic control of 149 institutionalized older adults were measured. Bayesian kernel machine regression was used to estimate the associations of the mixture of chemical elements with total cholesterol (TC), high-density lipoprotein (HDL-c), low-density lipoprotein (LDL-c), triglycerides (TG), fasting glucose, and glycated hemoglobin. ResultsNon-linear responses to exposure were observed for iron (Fe) about TC, LDL-c, and TG, and for barium (Ba) and copper (Cu) about TG. The concentration of the mixture of chemical elements below the 35th percentile was associated with a decrease in TC. Fe was the main element in the effect of the mixture associated with TC.ConclusionsThe lower concentrations of the mixture of chemical elements in plasma had a protective effect on the increase in TC, with Fe being the main element. Considering the results, the levels of essential and toxic elements in the plasma of older adults require extensive screening, mainly to prevent dyslipidemia and monitor clinical interventions