Navegando por Autor "Friedman, Rogerio"
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Artigo Agreement between software programmes of body composition analyses on abdominal computed tomography scans of obese adults(Endocrinology and Metabolism, 2020) Fayh, Ana Paula Trussardi; Barbalho, Erica Roberta; Rocha, Ilanna Marques Gomes da; Medeiros, Galtieri Otávio Cunha de; Friedman, RogerioObjective: A large number of studies have used abdominal computed tomography (CT) to quantify body composition, and different software programmes have been used to perform these analyses. Thus, this comparison is important to enable researchers to know the performance of more accessible software. Subjects and methods: Fifty-four abdominal CT scans of obese (BMI 30 to 39.9 kg/m²), sedentary adults (24-41 years) patients from a Brazilian single center were selected. Two software programs were compared: Slice-O-Matic (Tomovision, Canada) version 5.0 and OsiriX version 5.8.5. The body composition analysis were segmented using standard Hounsfield unit (HU) (adipose tissue: -190 to +30 and skeletal muscle: -29 to +150) and measured at the mid third lumbar vertebra (L3) level on a slice showing both transversal processes. Bland-Altman limits of agreement analyses were used to assess the level of agreement between Slice-O-Matic and OsiriX. Results: A total of fifty four participants were evaluated, with majority women (69%), mean of age 31.3 (SD 6.5) years and obesity grade I most prevalent (74.1%). The agreement, in Bland-Altman analysis, between Slice O-Matic and OsiriX analisys for the muscle mass tissue, visceral adipose tissue and subcutaneous adipose tissue were excellent (≥ 0.954) with P-values < 0.001. Conclusion: These findings show that Slice-O-Matic and OsiriX softwares agreement in measurements of skeletal muscle and adipose tissue and sarcopenia diagnosis in obese patients, suggesting good applicability in studies with body composition in this population and clinical practiceArtigo Appetite hormones in children and adolescents with cancer: a systematic review of observational studies(Nutrición Hospitalaria, 2018) Fayh, Ana Paula Trussardi; Bezerra, Agnes Denise de Lima; Friedman, RogerioIntroduction: Malnutrition in children with cancer is a significant risk factor for negative outcomes, but in the clinical practice setting, it is difficult to pinpoint which factors operate to cause substantial weight loss and malnutrition in a given patient. Appetite-related hormones like ghrelin and leptin are among possible mediators. However, only few studies have examined the role of these hormones in pediatric patients with cancer to date. Thus, the purpose of this study was to systematically review possible changes in the levels of appetite hormones, specially leptin and ghrelin, in pediatric patients with cancer. Material and methods: We systematically reviewed the literature using PubMed, Lilacs and Scielo, as well as manual bibliographical reference search of the studies. According to the Medical Subject Headings of the National Library of Medicine (MeSH), “childhood cancer”, “ghrelin” and “leptin” were used as descriptors. Results: Fifteen studies were included in this systematic review published in English, from 2000 to 2015. A total of 863 patients were evaluated, ages ranging from 0 to 21 years, and most of the studies reported on children and adolescents with acute lymphoblastic leukemia (ALL) survivors. Most studies analyzed leptin levels; only two studies evaluated levels of ghrelin. Conclusion: This review confirms that changes in the responses of the ghrelin and leptin hormones in children and adolescents with cancer are quite diverse, probably due to the different types of cancer observed, different treatments performed and biological characteristics of this age groupArtigo Effects of a single session of high-intensity interval exercise and moderate-intensity continuous exercise on biochemical cardiovascular risk factors in obese males(Sport Sciences for Health, 2018-02) Fayh, Ana Paula Trussardi; Matos, Victor Araújo Ferreira; Souza, Daniel Costa de; Santos, Victor Oliveira Albuquerque dos; Marinho, Cristiane da Silva Ramos; Serquiz, Alexandre Coelho; Friedman, Rogerio; Costa, Eduardo CaldasBackground: Few have analyzed the effects of different intensities of acute physical exercise on biochemical parameters of cardiovascular disease. Aim: To examine the acute effects of high-intensity interval exercise (HIIE) and moderate-intensity continuous exercise (MICE) on biochemical cardiovascular markers in obese male adults. Materials and methods: Twelve sedentary obese male subjects (28.4 ± 2.6 years old, BMI 35.5 ± 4.5 kg/m2, 39.8 ± 2.2% body fat) took part in this randomized, cross-over clinical trial. Three experimental sessions, at 7-day intervals, in random order, were carried out: (1) HIIE: 10 × 60 s at ~ 90% of maximal peak velocity, interspersed by 60 s of active recovery, (2) MICE: 20 min at ~ 70% of maximum heart rate, and (3) control session. A standardized breakfast was offered before the exercise sessions. Biochemical markers of cardiovascular risk (glycemia, total cholesterol and fractions, triglycerides, hepatic enzymes and nitrogen scores) were assessed pre-exercise, immediately post-exercise, and 60 min post-exercise. Results: In general, no significant interaction was observed, with the exception of creatinine, that had a statistically significant two-way interaction between time and condition, F(4,40) = 5.053, p < 0.05. There was a statistically significant two-way effect in time, F(2,22) = 5.906, p < 0.05 for AST, and a statistically significant two-way effect in treatment, F(2,22) = 13.477, p < 0.05 for glucose. Conclusion: In this context, HIIE seems to be a safe alternative to MICE for the prevention and management of obesity, as well as the disorders observed in this population